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- Fulvio Ursini
- Dipartmento di Chimica Biologica, Università di Padova, Viale G. Colombo 3, I-35121 Padova, Italy.
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- Sabina Heim
- National Research Centre for Biotechnology (GBF), Mascheroder Weg 1, D-38124 Braunschweig, Germany.
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- Michael Kiess
- National Research Centre for Biotechnology (GBF), Mascheroder Weg 1, D-38124 Braunschweig, Germany.
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- Matilde Maiorino
- Dipartmento di Chimica Biologica, Università di Padova, Viale G. Colombo 3, I-35121 Padova, Italy.
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- Antonella Roveri
- Dipartmento di Chimica Biologica, Università di Padova, Viale G. Colombo 3, I-35121 Padova, Italy.
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- Josef Wissing
- National Research Centre for Biotechnology (GBF), Mascheroder Weg 1, D-38124 Braunschweig, Germany.
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- Leopold Flohé
- Department of Biochemistry, Technical University of Braunschweig, Mascheroder Weg 1, D-38124 Braunschweig, Germany.
抄録
<jats:p>The selenoprotein phospholipid hydroperoxide glutathione peroxidase (PHGPx) changes its physical characteristics and biological functions during sperm maturation. PHGPx exists as a soluble peroxidase in spermatids but persists in mature spermatozoa as an enzymatically inactive, oxidatively cross-linked, insoluble protein. In the midpiece of mature spermatozoa, PHGPx protein represents at least 50 percent of the capsule material that embeds the helix of mitochondria. The role of PHGPx as a structural protein may explain the mechanical instability of the mitochondrial midpiece that is observed in selenium deficiency.</jats:p>
収録刊行物
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- Science
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Science 285 (5432), 1393-1396, 1999-08-27
American Association for the Advancement of Science (AAAS)
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キーワード
詳細情報
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- CRID
- 1362825895067403264
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- NII論文ID
- 80011300618
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- ISSN
- 10959203
- 00368075
- http://id.crossref.org/issn/00368075
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- データソース種別
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- Crossref
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