CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells

• Janine Morales

  Department of Immunobiology, DNAX Research Institute, Palo Alto, CA 94304; Schering-Plough, Laboratory for Immunological Research, Dardilly, France; Schering-Plough Research Institute, Human Genome Research, Kenilworth, NJ 07033; Instituto Nacional de la Nutrición, México D.F., México; and Mammalian Genetics Laboratory, National Cancer Institute–Frederick Cancer Research and Development Center, Frederick, MD 21702

• Bernhard Homey

  Department of Immunobiology, DNAX Research Institute, Palo Alto, CA 94304; Schering-Plough, Laboratory for Immunological Research, Dardilly, France; Schering-Plough Research Institute, Human Genome Research, Kenilworth, NJ 07033; Instituto Nacional de la Nutrición, México D.F., México; and Mammalian Genetics Laboratory, National Cancer Institute–Frederick Cancer Research and Development Center, Frederick, MD 21702

• Alain P. Vicari

  Department of Immunobiology, DNAX Research Institute, Palo Alto, CA 94304; Schering-Plough, Laboratory for Immunological Research, Dardilly, France; Schering-Plough Research Institute, Human Genome Research, Kenilworth, NJ 07033; Instituto Nacional de la Nutrición, México D.F., México; and Mammalian Genetics Laboratory, National Cancer Institute–Frederick Cancer Research and Development Center, Frederick, MD 21702

• Susan Hudak

  Department of Immunobiology, DNAX Research Institute, Palo Alto, CA 94304; Schering-Plough, Laboratory for Immunological Research, Dardilly, France; Schering-Plough Research Institute, Human Genome Research, Kenilworth, NJ 07033; Instituto Nacional de la Nutrición, México D.F., México; and Mammalian Genetics Laboratory, National Cancer Institute–Frederick Cancer Research and Development Center, Frederick, MD 21702

• Elizabeth Oldham

  Department of Immunobiology, DNAX Research Institute, Palo Alto, CA 94304; Schering-Plough, Laboratory for Immunological Research, Dardilly, France; Schering-Plough Research Institute, Human Genome Research, Kenilworth, NJ 07033; Instituto Nacional de la Nutrición, México D.F., México; and Mammalian Genetics Laboratory, National Cancer Institute–Frederick Cancer Research and Development Center, Frederick, MD 21702

• Joseph Hedrick

  Department of Immunobiology, DNAX Research Institute, Palo Alto, CA 94304; Schering-Plough, Laboratory for Immunological Research, Dardilly, France; Schering-Plough Research Institute, Human Genome Research, Kenilworth, NJ 07033; Instituto Nacional de la Nutrición, México D.F., México; and Mammalian Genetics Laboratory, National Cancer Institute–Frederick Cancer Research and Development Center, Frederick, MD 21702

• Rocio Orozco

  Department of Immunobiology, DNAX Research Institute, Palo Alto, CA 94304; Schering-Plough, Laboratory for Immunological Research, Dardilly, France; Schering-Plough Research Institute, Human Genome Research, Kenilworth, NJ 07033; Instituto Nacional de la Nutrición, México D.F., México; and Mammalian Genetics Laboratory, National Cancer Institute–Frederick Cancer Research and Development Center, Frederick, MD 21702

• Neal G. Copeland

  Department of Immunobiology, DNAX Research Institute, Palo Alto, CA 94304; Schering-Plough, Laboratory for Immunological Research, Dardilly, France; Schering-Plough Research Institute, Human Genome Research, Kenilworth, NJ 07033; Instituto Nacional de la Nutrición, México D.F., México; and Mammalian Genetics Laboratory, National Cancer Institute–Frederick Cancer Research and Development Center, Frederick, MD 21702

• Nancy A. Jenkins

  Department of Immunobiology, DNAX Research Institute, Palo Alto, CA 94304; Schering-Plough, Laboratory for Immunological Research, Dardilly, France; Schering-Plough Research Institute, Human Genome Research, Kenilworth, NJ 07033; Instituto Nacional de la Nutrición, México D.F., México; and Mammalian Genetics Laboratory, National Cancer Institute–Frederick Cancer Research and Development Center, Frederick, MD 21702

• Leslie M. McEvoy

  Department of Immunobiology, DNAX Research Institute, Palo Alto, CA 94304; Schering-Plough, Laboratory for Immunological Research, Dardilly, France; Schering-Plough Research Institute, Human Genome Research, Kenilworth, NJ 07033; Instituto Nacional de la Nutrición, México D.F., México; and Mammalian Genetics Laboratory, National Cancer Institute–Frederick Cancer Research and Development Center, Frederick, MD 21702

• Albert Zlotnik

  Department of Immunobiology, DNAX Research Institute, Palo Alto, CA 94304; Schering-Plough, Laboratory for Immunological Research, Dardilly, France; Schering-Plough Research Institute, Human Genome Research, Kenilworth, NJ 07033; Instituto Nacional de la Nutrición, México D.F., México; and Mammalian Genetics Laboratory, National Cancer Institute–Frederick Cancer Research and Development Center, Frederick, MD 21702

抄録

In contrast to naive lymphocytes, memory/effector lymphocytes can access nonlymphoid effector sites and display restricted, often tissue-selective, migration behavior. The cutaneous lymphocyte-associated antigen (CLA) defines a subset of circulating memory T cells that selectively localize in cutaneous sites mediated in part by the interaction of CLA with its vascular ligand E-selectin. Here, we report the identification and characterization of a CC chemokine, cutaneous T cell-attracting chemokine (CTACK). Both human and mouse CTACK are detected only in skin by Southern and Northern blot analyses. Specifically, CTACK message is found in the mouse epidermis and in human keratinocytes, and anti-CTACK mAbs predominantly stain the epithelium. Finally, CTACK selectively attracts CLA + memory T cells. Taken together, these results suggest an important role for CTACK in recruitment of CLA + T cells to cutaneous sites. CTACK is predominantly expressed in the skin and selectively attracts a tissue-specific subpopulation of memory lymphocytes.

収録刊行物

• Proceedings of the National Academy of Sciences

  Proceedings of the National Academy of Sciences 96 (25), 14470-14475, 1999-12-07

  Proceedings of the National Academy of Sciences

キーワード

• Multidisciplinary

詳細情報

• CRID: 1363388843763455232
• NII論文ID: 80011457310
• DOI: 10.1073/pnas.96.25.14470
• ISSN: 10916490
• ISSN: 00278424
• Web Site: https://pnas.org/doi/pdf/10.1073/pnas.96.25.14470
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