Out of Eden: Stem Cells and Their Niches

DOI Web Site 被引用文献59件
  • Fiona M. Watt
    Keratinocyte Laboratory, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.
  • and Brigid L. M. Hogan
    Howard Hughes Medical Institute and Department of Cell Biology, Vanderbilt University Medical Centre, Nashville, TN 37232–2175, USA.

抄録

<jats:p>Stem cells are currently in the news for two reasons: the successful cultivation of human embryonic stem cell lines and reports that adult stem cells can differentiate into developmentally unrelated cell types, such as nerve cells into blood cells. Both intrinsic and extrinsic signals regulate stem cell fate and some of these signals have now been identified. Certain aspects of the stem cell microenvironment, or niche, are conserved between tissues, and this can be exploited in the application of stem cells to tissue replacement therapy.</jats:p>

収録刊行物

  • Science

    Science 287 (5457), 1427-1430, 2000-02-25

    American Association for the Advancement of Science (AAAS)

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