15-Deoxy-Δ <sup>12,14</sup> -prostaglandin J <sub>2</sub> inhibits multiple steps in the NF-κB signaling pathway

DOI Web Site 被引用文献33件
  • Daniel S. Straus
    Biomedical Sciences Division, University of California, Riverside, CA 92521; and Divisions of Cellular and Molecular Medicine, and Endocrinology and Metabolism, Department and School of Medicine, and Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA 92093
  • Gabriel Pascual
    Biomedical Sciences Division, University of California, Riverside, CA 92521; and Divisions of Cellular and Molecular Medicine, and Endocrinology and Metabolism, Department and School of Medicine, and Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA 92093
  • Mei Li
    Biomedical Sciences Division, University of California, Riverside, CA 92521; and Divisions of Cellular and Molecular Medicine, and Endocrinology and Metabolism, Department and School of Medicine, and Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA 92093
  • John S. Welch
    Biomedical Sciences Division, University of California, Riverside, CA 92521; and Divisions of Cellular and Molecular Medicine, and Endocrinology and Metabolism, Department and School of Medicine, and Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA 92093
  • Mercedes Ricote
    Biomedical Sciences Division, University of California, Riverside, CA 92521; and Divisions of Cellular and Molecular Medicine, and Endocrinology and Metabolism, Department and School of Medicine, and Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA 92093
  • Chin-Hui Hsiang
    Biomedical Sciences Division, University of California, Riverside, CA 92521; and Divisions of Cellular and Molecular Medicine, and Endocrinology and Metabolism, Department and School of Medicine, and Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA 92093
  • Lei Lei Sengchanthalangsy
    Biomedical Sciences Division, University of California, Riverside, CA 92521; and Divisions of Cellular and Molecular Medicine, and Endocrinology and Metabolism, Department and School of Medicine, and Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA 92093
  • Gourisankar Ghosh
    Biomedical Sciences Division, University of California, Riverside, CA 92521; and Divisions of Cellular and Molecular Medicine, and Endocrinology and Metabolism, Department and School of Medicine, and Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA 92093
  • Christopher K. Glass
    Biomedical Sciences Division, University of California, Riverside, CA 92521; and Divisions of Cellular and Molecular Medicine, and Endocrinology and Metabolism, Department and School of Medicine, and Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA 92093

抄録

<jats:p> Prostaglandin J <jats:sub>2</jats:sub> (PGJ <jats:sub>2</jats:sub> ) and its metabolites Δ <jats:sup>12</jats:sup> -PGJ <jats:sub>2</jats:sub> and 15-deoxy-Δ <jats:sup>12,14</jats:sup> -PGJ <jats:sub>2</jats:sub> (15d-PGJ <jats:sub>2</jats:sub> ) are naturally occurring derivatives of prostaglandin D <jats:sub>2</jats:sub> that have been suggested to exert antiinflammatory effects <jats:italic>in vivo</jats:italic> . 15d-PGJ <jats:sub>2</jats:sub> is a high-affinity ligand for the peroxisome proliferator-activated receptor γ (PPARγ) and has been demonstrated to inhibit the induction of inflammatory response genes, including inducible NO synthase and tumor necrosis factor α, in a PPARγ-dependent manner. We report here that 15d-PGJ <jats:sub>2</jats:sub> potently inhibits NF-κB-dependent transcription by two additional PPARγ-independent mechanisms. Several lines of evidence suggest that 15d-PGJ <jats:sub>2</jats:sub> directly inhibits NF-κB-dependent gene expression through covalent modifications of critical cysteine residues in IκB kinase and the DNA-binding domains of NF-κB subunits. These mechanisms act in combination to inhibit transactivation of the NF-κB target gene cyclooxygenase 2. Direct inhibition of NF-κB signaling by 15d-PGJ <jats:sub>2</jats:sub> may contribute to negative regulation of prostaglandin biosynthesis and inflammation, suggesting additional approaches to the development of antiinflammatory drugs. </jats:p>

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