Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

DOI Web Site 被引用文献66件
  • Eri Oda
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.
  • Rieko Ohki
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.
  • Hideki Murasawa
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.
  • Jiro Nemoto
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.
  • Tsukasa Shibue
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.
  • Toshiharu Yamashita
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University School of Medicine, S1 W17, Chuo-Ku, Sapporo 060-8543, Japan.
  • Takashi Tokino
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University School of Medicine, S1 W17, Chuo-Ku, Sapporo 060-8543, Japan.
  • Tadatsugu Taniguchi
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.
  • † Nobuyuki Tanaka
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.

抄録

<jats:p> A critical function of tumor suppressor p53 is the induction of apoptosis in cells exposed to noxious stresses. We report a previously unidentified pro-apoptotic gene, <jats:italic>Noxa</jats:italic> . Expression of Noxa induction in primary mouse cells exposed to x-ray irradiation was dependent on p53. <jats:italic>Noxa</jats:italic> encodes a Bcl-2 homology 3 (BH3)–only member of the Bcl-2 family of proteins; this member contains the BH3 region but not other BH domains. When ectopically expressed, Noxa underwent BH3 motif–dependent localization to mitochondria and interacted with anti-apoptotic Bcl-2 family members, resulting in the activation of caspase-9. We also demonstrate that blocking the endogenous Noxa induction results in the suppression of apoptosis. Noxa may thus represent a mediator of p53-dependent apoptosis. </jats:p>

収録刊行物

  • Science

    Science 288 (5468), 1053-1058, 2000-05-12

    American Association for the Advancement of Science (AAAS)

被引用文献 (66)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ