Treatment of Murine Colitis by <i>Lactococcus lactis</i> Secreting Interleukin-10

DOI Web Site 被引用文献37件
  • Lothar Steidler
    Department of Molecular Biology, Ghent University and Flanders Interuniversity Institute for Biotechnology, K. L. Ledeganckstraat 35, 9000 Gent, Belgium.
  • Wolfgang Hans
    Department of Molecular Biology, Ghent University and Flanders Interuniversity Institute for Biotechnology, K. L. Ledeganckstraat 35, 9000 Gent, Belgium.
  • Lieven Schotte
    Department of Molecular Biology, Ghent University and Flanders Interuniversity Institute for Biotechnology, K. L. Ledeganckstraat 35, 9000 Gent, Belgium.
  • Sabine Neirynck
    Department of Molecular Biology, Ghent University and Flanders Interuniversity Institute for Biotechnology, K. L. Ledeganckstraat 35, 9000 Gent, Belgium.
  • Florian Obermeier
    Department of Internal Medicine I, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93042 Regensburg, Germany.
  • Werner Falk
    Department of Internal Medicine I, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93042 Regensburg, Germany.
  • Walter Fiers
    Department of Molecular Biology, Ghent University and Flanders Interuniversity Institute for Biotechnology, K. L. Ledeganckstraat 35, 9000 Gent, Belgium.
  • Erik Remaut
    Department of Molecular Biology, Ghent University and Flanders Interuniversity Institute for Biotechnology, K. L. Ledeganckstraat 35, 9000 Gent, Belgium.

抄録

<jats:p> The cytokine interleukin-10 (IL-10) has shown promise in clinical trials for treatment of inflammatory bowel disease (IBD). Using two mouse models, we show that the therapeutic dose of IL-10 can be reduced by localized delivery of a bacterium genetically engineered to secrete the cytokine. Intragastric administration of IL-10–secreting <jats:italic>Lactococcus lactis</jats:italic> caused a 50% reduction in colitis in mice treated with dextran sulfate sodium and prevented the onset of colitis in IL-10 <jats:sup>−/−</jats:sup> mice. This approach may lead to better methods for cost-effective and long-term management of IBD in humans. </jats:p>

収録刊行物

  • Science

    Science 289 (5483), 1352-1355, 2000-08-25

    American Association for the Advancement of Science (AAAS)

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