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- Brad St. Croix
- Johns Hopkins Oncology Center,
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- Carlo Rago
- Johns Hopkins Oncology Center,
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- Victor Velculescu
- Johns Hopkins Oncology Center,
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- Giovanni Traverso
- Johns Hopkins Oncology Center,
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- Katharine E. Romans
- Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
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- Elizabeth Montgomery
- Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
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- Anita Lal
- Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA.
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- Gregory J. Riggins
- Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA.
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- Christoph Lengauer
- Johns Hopkins Oncology Center,
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- Bert Vogelstein
- Johns Hopkins Oncology Center,
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- Kenneth W. Kinzler
- Johns Hopkins Oncology Center,
抄録
<jats:p>To gain a molecular understanding of tumor angiogenesis, we compared gene expression patterns of endothelial cells derived from blood vessels of normal and malignant colorectal tissues. Of over 170 transcripts predominantly expressed in the endothelium, 79 were differentially expressed, including 46 that were specifically elevated in tumor-associated endothelium. Several of these genes encode extracellular matrix proteins, but most are of unknown function. Most of these tumor endothelial markers were expressed in a wide range of tumor types, as well as in normal vessels associated with wound healing and corpus luteum formation. These studies demonstrate that tumor and normal endothelium are distinct at the molecular level, a finding that may have significant implications for the development of anti-angiogenic therapies.</jats:p>
収録刊行物
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- Science
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Science 289 (5482), 1197-1202, 2000-08-18
American Association for the Advancement of Science (AAAS)
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キーワード
詳細情報 詳細情報について
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- CRID
- 1360292620685244160
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- NII論文ID
- 80012004846
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- ISSN
- 10959203
- 00368075
- http://id.crossref.org/issn/00368075
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- データソース種別
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- Crossref
- CiNii Articles