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- Obadiah J. Plante
- Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
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- Emma R. Palmacci
- Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
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- Peter H. Seeberger
- Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
抄録
<jats:p>Traditionally, access to structurally defined complex carbohydrates has been very laborious. Although recent advancements in solid-phase synthesis have made the construction of complex oligosaccharides less tedious, a high level of technical expertise is still necessary to obtain the desired structures. We describe the automated chemical synthesis of several oligosaccharides on a solid-phase synthesizer. A branched dodecasaccharide was synthesized through the use of glycosyl phosphate building blocks and an octenediol functionalized resin. The target oligosaccharide was readily obtained after cleavage from the solid support. Access to certain complex oligosaccharides now has become feasible in a fashion much like the construction of oligopeptides and oligonucleotides.</jats:p>
収録刊行物
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- Science
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Science 291 (5508), 1523-1527, 2001-02-23
American Association for the Advancement of Science (AAAS)
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キーワード
詳細情報 詳細情報について
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- CRID
- 1360011144939137408
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- NII論文ID
- 80012329680
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- ISSN
- 10959203
- 00368075
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- データソース種別
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