Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

• J. William Langston

• Philip Ballard

• James W. Tetrud

• Ian Irwin

抄録

Four persons developed marked parkinsonism after using an illicit drug intravenously. Analysis of the substance injected by two of these patients revealed primarily 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) with trace amounts of 1-methyl-4-phenyl-4-propionoxy-piperidine (MPPP). On the basis of the striking parkinsonian features observed in our patients, and additional pathological data from one previously reported case, it is proposed that this chemical selectively damages cells in the substantia nigra.

収録刊行物

• Science

  Science 219 (4587), 979-980, 1983-02-25

  American Association for the Advancement of Science (AAAS)

キーワード

• Multidisciplinary

詳細情報

• CRID: 1364233269554104576
• NII論文ID: 80014351486
• DOI: 10.1126/science.6823561
• ISSN: 10959203
• ISSN: 00368075
• ISSN: http://id.crossref.org/issn/00368075
• Web Site: https://www.science.org/doi/pdf/10.1126/science.6823561
• データソース種別:
  • Crossref
  • CiNii Articles