IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions

DOI Web Site 被引用文献63件
  • Hiroshi Konishi
    Departments of Dermatology and Biochemistry, and Institute of Laboratory Animals, Mie University School of Medicine, Tsu 514-8507, Japan; Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya 663-8501, Japan; Laboratory Animal Research Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan; Department of Host Defenses, Research Institute for Microbial Diseases, Suita 565-0871, Japan; and Core Research for Evolutional Science and Technology,...
  • Hiroko Tsutsui
    Departments of Dermatology and Biochemistry, and Institute of Laboratory Animals, Mie University School of Medicine, Tsu 514-8507, Japan; Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya 663-8501, Japan; Laboratory Animal Research Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan; Department of Host Defenses, Research Institute for Microbial Diseases, Suita 565-0871, Japan; and Core Research for Evolutional Science and Technology,...
  • Takaaki Murakami
    Departments of Dermatology and Biochemistry, and Institute of Laboratory Animals, Mie University School of Medicine, Tsu 514-8507, Japan; Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya 663-8501, Japan; Laboratory Animal Research Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan; Department of Host Defenses, Research Institute for Microbial Diseases, Suita 565-0871, Japan; and Core Research for Evolutional Science and Technology,...
  • Shizue Yumikura-Futatsugi
    Departments of Dermatology and Biochemistry, and Institute of Laboratory Animals, Mie University School of Medicine, Tsu 514-8507, Japan; Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya 663-8501, Japan; Laboratory Animal Research Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan; Department of Host Defenses, Research Institute for Microbial Diseases, Suita 565-0871, Japan; and Core Research for Evolutional Science and Technology,...
  • Kei-ichi Yamanaka
    Departments of Dermatology and Biochemistry, and Institute of Laboratory Animals, Mie University School of Medicine, Tsu 514-8507, Japan; Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya 663-8501, Japan; Laboratory Animal Research Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan; Department of Host Defenses, Research Institute for Microbial Diseases, Suita 565-0871, Japan; and Core Research for Evolutional Science and Technology,...
  • Minoru Tanaka
    Departments of Dermatology and Biochemistry, and Institute of Laboratory Animals, Mie University School of Medicine, Tsu 514-8507, Japan; Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya 663-8501, Japan; Laboratory Animal Research Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan; Department of Host Defenses, Research Institute for Microbial Diseases, Suita 565-0871, Japan; and Core Research for Evolutional Science and Technology,...
  • Yohichiro Iwakura
    Departments of Dermatology and Biochemistry, and Institute of Laboratory Animals, Mie University School of Medicine, Tsu 514-8507, Japan; Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya 663-8501, Japan; Laboratory Animal Research Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan; Department of Host Defenses, Research Institute for Microbial Diseases, Suita 565-0871, Japan; and Core Research for Evolutional Science and Technology,...
  • Noboru Suzuki
    Departments of Dermatology and Biochemistry, and Institute of Laboratory Animals, Mie University School of Medicine, Tsu 514-8507, Japan; Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya 663-8501, Japan; Laboratory Animal Research Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan; Department of Host Defenses, Research Institute for Microbial Diseases, Suita 565-0871, Japan; and Core Research for Evolutional Science and Technology,...
  • Kiyoshi Takeda
    Departments of Dermatology and Biochemistry, and Institute of Laboratory Animals, Mie University School of Medicine, Tsu 514-8507, Japan; Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya 663-8501, Japan; Laboratory Animal Research Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan; Department of Host Defenses, Research Institute for Microbial Diseases, Suita 565-0871, Japan; and Core Research for Evolutional Science and Technology,...
  • Shizuo Akira
    Departments of Dermatology and Biochemistry, and Institute of Laboratory Animals, Mie University School of Medicine, Tsu 514-8507, Japan; Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya 663-8501, Japan; Laboratory Animal Research Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan; Department of Host Defenses, Research Institute for Microbial Diseases, Suita 565-0871, Japan; and Core Research for Evolutional Science and Technology,...
  • Kenji Nakanishi
    Departments of Dermatology and Biochemistry, and Institute of Laboratory Animals, Mie University School of Medicine, Tsu 514-8507, Japan; Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya 663-8501, Japan; Laboratory Animal Research Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan; Department of Host Defenses, Research Institute for Microbial Diseases, Suita 565-0871, Japan; and Core Research for Evolutional Science and Technology,...
  • Hitoshi Mizutani
    Departments of Dermatology and Biochemistry, and Institute of Laboratory Animals, Mie University School of Medicine, Tsu 514-8507, Japan; Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya 663-8501, Japan; Laboratory Animal Research Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan; Department of Host Defenses, Research Institute for Microbial Diseases, Suita 565-0871, Japan; and Core Research for Evolutional Science and Technology,...

抄録

<jats:p>Atopic dermatitis (AD) is a pruritic inflammatory skin disease. Because IL-18 directly stimulates T cells and mast cells to release AD-associated molecules, Th2 cytokines, and histamine, we investigated the capacity of IL-18 to induce AD-like inflammatory skin disease by analyzing KIL-18Tg and KCASP1Tg, which skin-specifically overexpress IL-18 and caspase-1, respectively. They spontaneously developed relapsing dermatitis with mastocytosis and Th2 cytokine accumulation accompanied by systemic elevation of IgE and histamine. Stat6-deficient KCASP1Tg displayed undetectable levels of IgE but manifested the same degree of cutaneous changes, whereas IL-18-deficient KCASP1Tg evaded the dermatitis, suggesting that IL-18 causes the skin changes in the absence of IgE/stat6. KIL-18Tg and IL-1-deficient KCASP1Tg took longer to display the lesion than KCASP1Tg. Thus, AD-like inflammation is initiated by overrelease of IL-18 and accelerated by IL-1. Our present study might provide insight into understanding the pathogenesis of and establishing therapeutics for chronic inflammatory skin diseases including AD.</jats:p>

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