Nanocrystal targeting <i>in vivo</i>

• Maria E. Åkerman

  Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037; and Department of Bioengineering, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093

• Warren C. W. Chan

  Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037; and Department of Bioengineering, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093

• Pirjo Laakkonen

  Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037; and Department of Bioengineering, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093

• Sangeeta N. Bhatia

  Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037; and Department of Bioengineering, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093

• Erkki Ruoslahti

  Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037; and Department of Bioengineering, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093

抄録

Inorganic nanostructures that interface with biological systems have recently attracted widespread interest in biology and medicine. Nanoparticles are thought to have potential as novel intravascular probes for both diagnostic (e.g., imaging) and therapeutic purposes (e.g., drug delivery). Critical issues for successful nanoparticle delivery include the ability to target specific tissues and cell types and escape from the biological particulate filter known as the reticuloendothelial system. We set out to explore the feasibility of in vivo targeting by using semiconductor quantum dots (qdots). Qdots are small (<10 nm) inorganic nanocrystals that possess unique luminescent properties; their fluorescence emission is stable and tuned by varying the particle size or composition. We show that ZnS-capped CdSe qdots coated with a lung-targeting peptide accumulate in the lungs of mice after i.v. injection, whereas two other peptides specifically direct qdots to blood vessels or lymphatic vessels in tumors. We also show that adding polyethylene glycol to the qdot coating prevents nonselective accumulation of qdots in reticuloendothelial tissues. These results encourage the construction of more complex nanostructures with capabilities such as disease sensing and drug delivery.

収録刊行物

• Proceedings of the National Academy of Sciences

  Proceedings of the National Academy of Sciences 99 (20), 12617-12621, 2002-09-16

  Proceedings of the National Academy of Sciences

キーワード

• Multidisciplinary

詳細情報

• CRID: 1361418520098578816
• NII論文ID: 80015615320
• DOI: 10.1073/pnas.152463399
• ISSN: 10916490
• ISSN: 00278424
• Web Site: https://pnas.org/doi/pdf/10.1073/pnas.152463399
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