A Stem Cell Molecular Signature

DOI Web Site 被引用文献28件
  • Natalia B. Ivanova
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
  • John T. Dimos
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
  • Christoph Schaniel
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
  • Jason A. Hackney
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
  • Kateri A. Moore
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
  • Ihor R. Lemischka
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.

抄録

<jats:p>Mechanisms regulating self-renewal and cell fate decisions in mammalian stem cells are poorly understood. We determined global gene expression profiles for mouse and human hematopoietic stem cells and other stages of the hematopoietic hierarchy. Murine and human hematopoietic stem cells share a number of expressed gene products, which define key conserved regulatory pathways in this developmental system. Moreover, in the mouse, a portion of the genetic program of hematopoietic stem cells is shared with embryonic and neural stem cells. This overlapping set of gene products represents a molecular signature of stem cells.</jats:p>

収録刊行物

  • Science

    Science 298 (5593), 601-604, 2002-10-18

    American Association for the Advancement of Science (AAAS)

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