Genome sequence of <i>Streptococcus mutans</i> UA159, a cariogenic dental pathogen

• Dragana Ajdić

  Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; and Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019

• William M. McShan

  Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; and Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019

• Robert E. McLaughlin

  Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; and Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019

• Gorana Savić

  Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; and Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019

• Jin Chang

  Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; and Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019

• Matthew B. Carson

  Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; and Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019

• Charles Primeaux

  Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; and Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019

• Runying Tian

  Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; and Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019

• Steve Kenton

  Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; and Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019

• Honggui Jia

  Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; and Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019

• Shaoping Lin

  Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; and Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019

• Yudong Qian

  Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; and Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019

• Shuling Li

  Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; and Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019

• Hua Zhu

  Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; and Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019

• Fares Najar

  Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; and Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019

• Hongshing Lai

  Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; and Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019

• Jim White

  Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; and Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019

• Bruce A. Roe

  Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; and Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019

• Joseph J. Ferretti

  Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; and Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019

抄録

Streptococcus mutans is the leading cause of dental caries (tooth decay) worldwide and is considered to be the most cariogenic of all of the oral streptococci. The genome of S. mutans UA159, a serotype c strain, has been completely sequenced and is composed of 2,030,936 base pairs. It contains 1,963 ORFs, 63% of which have been assigned putative functions. The genome analysis provides further insight into how S. mutans has adapted to surviving the oral environment through resource acquisition, defense against host factors, and use of gene products that maintain its niche against microbial competitors. S. mutans metabolizes a wide variety of carbohydrates via nonoxidative pathways, and all of these pathways have been identified, along with the associated transport systems whose genes account for almost 15% of the genome. Virulence genes associated with extracellular adherent glucan production, adhesins, acid tolerance, proteases, and putative hemolysins have been identified. Strain UA159 is naturally competent and contains all of the genes essential for competence and quorum sensing. Mobile genetic elements in the form of IS elements and transposons are prominent in the genome and include a previously uncharacterized conjugative transposon and a composite transposon containing genes for the synthesis of antibiotics of the gramicidin/bacitracin family; however, no bacteriophage genomes are present.

収録刊行物

• Proceedings of the National Academy of Sciences

  Proceedings of the National Academy of Sciences 99 (22), 14434-14439, 2002-10-23

  Proceedings of the National Academy of Sciences

キーワード

• Multidisciplinary

詳細情報

• CRID: 1363670321209938688
• NII論文ID: 80015652199
• DOI: 10.1073/pnas.172501299
• ISSN: 10916490
• ISSN: 00278424
• Web Site: https://pnas.org/doi/pdf/10.1073/pnas.172501299
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