Trophoblast L-Selectin-Mediated Adhesion at the Maternal-Fetal Interface

• Olga D. Genbacev

• Akraporn Prakobphol

• Russell A. Foulk

• Ana R. Krtolica

• Dusko Ilic

• Mark S. Singer

• Zhi-Qiang Yang

• Laura L. Kiessling

• Steven D. Rosen

• Susan J. Fisher

Abstract

Trophoblast adhesion to the uterine wall is the requisite first step of implantation and, subsequently, placentation. At the maternal-fetal interface, we investigated the expression of selectin adhesion systems that enable leukocyte capture from the bloodstream. On the maternal side, human uterine epithelial cells up-regulated selectin oligosaccharide-based ligands during the window of receptivity. On the fetal side, human trophoblasts expressed L-selectin. This ligand-receptor system was functional, because beads coated with the selectin ligand 6-sulfo sLe x bound to trophoblasts, and trophoblasts bound to ligand-expressing uterine luminal epithelium in tissue sections. These results suggest that trophoblast L-selectin mediates interactions with the uterus and that this adhesion mechanism may be critical to establishing human pregnancy.

Journal

• Science

  Science 299 (5605), 405-408, 2003-01-17

  American Association for the Advancement of Science (AAAS)

Keywords

• Multidisciplinary

Details

• CRID: 1361137045915701760
• NII Article ID: 80015763266
• DOI: 10.1126/science.1079546
• ISSN: 10959203
• ISSN: 00368075
• ISSN: http://id.crossref.org/issn/00368075
• Web Site: https://www.science.org/doi/pdf/10.1126/science.1079546
• Data Source:
  • Crossref
  • CiNii Articles