One-Way Control of <i>FWA</i> Imprinting in <i>Arabidopsis</i> Endosperm by DNA Methylation

DOI Web Site 被引用文献53件
  • Tetsu Kinoshita
    Integrated Genetics, National Institute of Genetics, Mishima 411-8540, Japan.
  • Asuka Miura
    Integrated Genetics, National Institute of Genetics, Mishima 411-8540, Japan.
  • Yeonhee Choi
    Integrated Genetics, National Institute of Genetics, Mishima 411-8540, Japan.
  • Yuki Kinoshita
    Integrated Genetics, National Institute of Genetics, Mishima 411-8540, Japan.
  • Xiaofeng Cao
    Integrated Genetics, National Institute of Genetics, Mishima 411-8540, Japan.
  • Steven E. Jacobsen
    Integrated Genetics, National Institute of Genetics, Mishima 411-8540, Japan.
  • Robert L. Fischer
    Integrated Genetics, National Institute of Genetics, Mishima 411-8540, Japan.
  • Tetsuji Kakutani
    Integrated Genetics, National Institute of Genetics, Mishima 411-8540, Japan.

抄録

<jats:p> The <jats:italic>Arabidopsis FWA</jats:italic> gene was initially identified from late-flowering epigenetic mutants that show ectopic <jats:italic>FWA</jats:italic> expression associated with heritable hypomethylation of repeats around transcription starting sites. Here, we show that wild-type <jats:italic>FWA</jats:italic> displays imprinted (maternal origin–specific) expression in endosperm. The <jats:italic>FWA</jats:italic> imprint depends on the maintenance DNA methyltransferase MET1, as is the case in mammals. Unlike mammals, however, the <jats:italic>FWA</jats:italic> imprint is not established by allele-specific de novo methylation. It is established by maternal gametophyte–specific gene activation, which depends on a DNA glycosylase gene, <jats:italic>DEMETER</jats:italic> . Because endosperm does not contribute to the next generation, the activated <jats:italic>FWA</jats:italic> gene need not be silenced again. Double fertilization enables plants to use such “one-way” control of imprinting and DNA methylation in endosperm. </jats:p>

収録刊行物

  • Science

    Science 303 (5657), 521-523, 2004-01-23

    American Association for the Advancement of Science (AAAS)

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