Epidemiological and sequence differences between two subtypes (Ae and Aa) of hepatitis B virus genotype A

DOI Web Site 被引用文献20件
  • Fuminaka Sugauchi
    Departments of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
  • Hiromitsu Kumada
    Department of Gastroenterology, Toranomon Hospital, Tokyo, Japan
  • Subrat A. Acharya
    Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India
  • Santosh Man Shrestha
    Liver Foundation Nepal, Nepal
  • Maria Teresita A. Gamutan
    SanJuan de Dios Hospital, The Philippines
  • Mobin Khan
    Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
  • Robert G. Gish
    Hepatology and Gastroenterology, California Pacific Medical Center, San Francisco, USA
  • Yasuhito Tanaka
    Departments of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
  • Takanobu Kato
    Departments of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
  • Etsuro Orito
    Departments of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
  • Ryuzo Ueda
    Departments of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
  • Yuzo Miyakawa
    Miyakawa Memorial Research Foundation, Tokyo, Japan
  • Masashi Mizokami
    Departments of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan

抄録

<jats:p>Complete nucleotide sequences of 19 hepatitis B virus (HBV) isolates of genotype A (HBV/A) were determined and analysed along with those of 20 previously reported HBV/A isolates. Of the 19 HBV/A isolates, six including three from Japan and three from the USA clustered with the 14 HBV/A isolates from Western countries. The remaining 13 isolates including four from The Philippines, two from India, three from Nepal and four from Bangladesh clustered with the six HBV/A isolates reported from The Philippines, South Africa and Malawi. Due to distinct epidemiological distributions, genotype A in the 20 HBV isolates was classified into subtype Ae (e for Europe), and that in the other 19 into subtype Aa (a for Asia and Africa) provisionally. The 19 HBV/Aa isolates had a sequence variation significantly greater than that of the 20 HBV/Ae isolates (2·5±0·3 % vs 1·1±0·6 %, <jats:italic>P</jats:italic><0·0001); they differed by 5·0±0·4 % (4·1–6·4 %). The double mutation (T1762/A1764) in the core promoter was significantly more frequent in HBV/Aa isolates than in HBV/Ae isolates (11/19 or 58 % vs 5/20 or 25 %, <jats:italic>P</jats:italic><0·01). In the pregenome encapsidation (<jats:italic>ε</jats:italic>) signal, a point mutation from G to A or T at nt 1862 was detected in 16 of the 19 (84 %) HBV/Aa isolates but not in any of the 20 HBV/Ae isolates, which may affect virus replication and translation of hepatitis B e antigen. Subtypes Aa and Ae of genotype A deserve evaluation for any clinical differences between them, with a special reference to hepatocellular carcinoma prevalent in Africa.</jats:p>

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