Trophic Action of Leptin on Hypothalamic Neurons That Regulate Feeding

DOI Web Site 被引用文献18件
  • Sebastien G. Bouret
    Division of Neuroscience, Oregon National Primate Research Center and Oregon Health and Science University, Beaverton, OR 97006, USA.
  • Shin J. Draper
    Division of Neuroscience, Oregon National Primate Research Center and Oregon Health and Science University, Beaverton, OR 97006, USA.
  • Richard B. Simerly
    Division of Neuroscience, Oregon National Primate Research Center and Oregon Health and Science University, Beaverton, OR 97006, USA.

抄録

<jats:p> In adult mammals, the adipocyte-derived hormone leptin acts on the brain to reduce food intake by regulating the activity of neurons in the arcuate nucleus of the hypothalamus (ARH). Here, we report that neural projection pathways from the ARH are permanently disrupted in leptin-deficient (Lep <jats:sup>ob</jats:sup> /Lep <jats:sup>ob</jats:sup> ) mice and leptin treatment in adulthood does not reverse these neuroanatomical defects. However, treatment of Lep <jats:sup>ob</jats:sup> /Lep <jats:sup>ob</jats:sup> neonates with exogenous leptin rescues the development of ARH projections, and leptin promotes neurite outgrowth from ARH neurons in vitro. These results suggest that leptin plays a neurotrophic role during the development of the hypothalamus and that this activity is restricted to a neonatal critical period that precedes leptin's acute regulation of food intake in adults. </jats:p>

収録刊行物

  • Science

    Science 304 (5667), 108-110, 2004-04-02

    American Association for the Advancement of Science (AAAS)

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