Intracellular Parasite Invasion Strategies

DOI Web Site 9 Citations
  • L. D. Sibley
    Department of Molecular Microbiology, Center for Infectious Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA.

Abstract

<jats:p> Intracellular parasites use various strategies to invade cells and to subvert cellular signaling pathways and, thus, to gain a foothold against host defenses. Efficient cell entry, ability to exploit intracellular niches, and persistence make these parasites treacherous pathogens. Most intracellular parasites gain entry via host-mediated processes, but apicomplexans use a system of adhesion-based motility called “gliding” to actively penetrate host cells. Actin polymerization–dependent motility facilitates parasite migration across cellular barriers, enables dissemination within tissues, and powers invasion of host cells. Efficient invasion has brought widespread success to this group, which includes <jats:italic>Toxoplasma, Plasmodium</jats:italic> , and <jats:italic>Cryptosporidium</jats:italic> . </jats:p>

Journal

  • Science

    Science 304 (5668), 248-253, 2004-04-09

    American Association for the Advancement of Science (AAAS)

Citations (9)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top