Functional Adaptation of BabA, the <i>H. pylori</i> ABO Blood Group Antigen Binding Adhesin

DOI Web Site 被引用文献27件
  • Marina Aspholm-Hurtig
    Department of Odontology, section of Oral Microbiology, Umeå University, SE-901 87 Umeå, Sweden.
  • Giedrius Dailide
    Department of Odontology, section of Oral Microbiology, Umeå University, SE-901 87 Umeå, Sweden.
  • Martina Lahmann
    Department of Odontology, section of Oral Microbiology, Umeå University, SE-901 87 Umeå, Sweden.
  • Awdhesh Kalia
    Department of Odontology, section of Oral Microbiology, Umeå University, SE-901 87 Umeå, Sweden.
  • Dag Ilver
    Department of Odontology, section of Oral Microbiology, Umeå University, SE-901 87 Umeå, Sweden.
  • Niamh Roche
    Department of Odontology, section of Oral Microbiology, Umeå University, SE-901 87 Umeå, Sweden.
  • Susanne Vikström
    Department of Odontology, section of Oral Microbiology, Umeå University, SE-901 87 Umeå, Sweden.
  • Rolf Sjöström
    Department of Odontology, section of Oral Microbiology, Umeå University, SE-901 87 Umeå, Sweden.
  • Sara Lindén
    Department of Odontology, section of Oral Microbiology, Umeå University, SE-901 87 Umeå, Sweden.
  • Anna Bäckström
    Department of Odontology, section of Oral Microbiology, Umeå University, SE-901 87 Umeå, Sweden.
  • Carina Lundberg
    Department of Odontology, section of Oral Microbiology, Umeå University, SE-901 87 Umeå, Sweden.
  • Anna Arnqvist
    Department of Odontology, section of Oral Microbiology, Umeå University, SE-901 87 Umeå, Sweden.
  • Jafar Mahdavi
    Department of Odontology, section of Oral Microbiology, Umeå University, SE-901 87 Umeå, Sweden.
  • Ulf J. Nilsson
    Department of Odontology, section of Oral Microbiology, Umeå University, SE-901 87 Umeå, Sweden.
  • Billie Velapatiño
    Department of Odontology, section of Oral Microbiology, Umeå University, SE-901 87 Umeå, Sweden.
  • Robert H. Gilman
    Department of Odontology, section of Oral Microbiology, Umeå University, SE-901 87 Umeå, Sweden.
  • Markus Gerhard
    Department of Odontology, section of Oral Microbiology, Umeå University, SE-901 87 Umeå, Sweden.
  • Teresa Alarcon
    Department of Odontology, section of Oral Microbiology, Umeå University, SE-901 87 Umeå, Sweden.
  • Manuel López-Brea
    Department of Odontology, section of Oral Microbiology, Umeå University, SE-901 87 Umeå, Sweden.
  • Teruko Nakazawa
    Department of Odontology, section of Oral Microbiology, Umeå University, SE-901 87 Umeå, Sweden.
  • James G. Fox
    Department of Odontology, section of Oral Microbiology, Umeå University, SE-901 87 Umeå, Sweden.
  • Pelayo Correa
    Department of Odontology, section of Oral Microbiology, Umeå University, SE-901 87 Umeå, Sweden.
  • Maria Gloria Dominguez-Bello
    Department of Odontology, section of Oral Microbiology, Umeå University, SE-901 87 Umeå, Sweden.
  • Guillermo I. Perez-Perez
    Department of Odontology, section of Oral Microbiology, Umeå University, SE-901 87 Umeå, Sweden.
  • Martin J. Blaser
    Department of Odontology, section of Oral Microbiology, Umeå University, SE-901 87 Umeå, Sweden.
  • Staffan Normark
    Department of Odontology, section of Oral Microbiology, Umeå University, SE-901 87 Umeå, Sweden.
  • Ingemar Carlstedt
    Department of Odontology, section of Oral Microbiology, Umeå University, SE-901 87 Umeå, Sweden.
  • Stefan Oscarson
    Department of Odontology, section of Oral Microbiology, Umeå University, SE-901 87 Umeå, Sweden.
  • Susann Teneberg
    Department of Odontology, section of Oral Microbiology, Umeå University, SE-901 87 Umeå, Sweden.
  • Douglas E. Berg
    Department of Odontology, section of Oral Microbiology, Umeå University, SE-901 87 Umeå, Sweden.
  • Thomas Borén
    Department of Odontology, section of Oral Microbiology, Umeå University, SE-901 87 Umeå, Sweden.

抄録

<jats:p> Adherence by <jats:italic>Helicobacter pylori</jats:italic> increases the risk of gastric disease. Here, we report that more than 95% of strains that bind fucosylated blood group antigen bind A, B, and O antigens (generalists), whereas 60% of adherent South American Amerindian strains bind blood group O antigens best (specialists). This specialization coincides with the unique predominance of blood group O in these Amerindians. Strains differed about 1500-fold in binding affinities, and diversifying selection was evident in <jats:italic>babA</jats:italic> sequences. We propose that cycles of selection for increased and decreased bacterial adherence contribute to <jats:italic>babA</jats:italic> diversity and that these cycles have led to gradual replacement of generalist binding by specialist binding in blood group O–dominant human populations. </jats:p>

収録刊行物

  • Science

    Science 305 (5683), 519-522, 2004-07-23

    American Association for the Advancement of Science (AAAS)

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