Derivatives of Erythropoietin That Are Tissue Protective But Not Erythropoietic

• Marcel Leist

  H. Lundbeck A/S, 2500 Valby, Denmark.

• Pietro Ghezzi

  H. Lundbeck A/S, 2500 Valby, Denmark.

• Giovanni Grasso

  H. Lundbeck A/S, 2500 Valby, Denmark.

• Roberto Bianchi

  H. Lundbeck A/S, 2500 Valby, Denmark.

• Pia Villa

  H. Lundbeck A/S, 2500 Valby, Denmark.

• Maddalena Fratelli

  H. Lundbeck A/S, 2500 Valby, Denmark.

• Costanza Savino

  H. Lundbeck A/S, 2500 Valby, Denmark.

• Marina Bianchi

  H. Lundbeck A/S, 2500 Valby, Denmark.

• Jacob Nielsen

  H. Lundbeck A/S, 2500 Valby, Denmark.

• Jens Gerwien

  H. Lundbeck A/S, 2500 Valby, Denmark.

• Pekka Kallunki

  H. Lundbeck A/S, 2500 Valby, Denmark.

• Anna Kirstine Larsen

  H. Lundbeck A/S, 2500 Valby, Denmark.

• Lone Helboe

  H. Lundbeck A/S, 2500 Valby, Denmark.

• Søren Christensen

  H. Lundbeck A/S, 2500 Valby, Denmark.

• Lars O. Pedersen

  H. Lundbeck A/S, 2500 Valby, Denmark.

• Mette Nielsen

  H. Lundbeck A/S, 2500 Valby, Denmark.

• Lars Torup

  H. Lundbeck A/S, 2500 Valby, Denmark.

• Thomas Sager

  H. Lundbeck A/S, 2500 Valby, Denmark.

• Alessandra Sfacteria

  H. Lundbeck A/S, 2500 Valby, Denmark.

• Serhat Erbayraktar

  H. Lundbeck A/S, 2500 Valby, Denmark.

• Zubeyde Erbayraktar

  H. Lundbeck A/S, 2500 Valby, Denmark.

• Necati Gokmen

  H. Lundbeck A/S, 2500 Valby, Denmark.

• Osman Yilmaz

  H. Lundbeck A/S, 2500 Valby, Denmark.

• Carla Cerami-Hand

  H. Lundbeck A/S, 2500 Valby, Denmark.

• Qiao-wen Xie

  H. Lundbeck A/S, 2500 Valby, Denmark.

• Thomas Coleman

  H. Lundbeck A/S, 2500 Valby, Denmark.

• Anthony Cerami

  H. Lundbeck A/S, 2500 Valby, Denmark.

• Michael Brines

  H. Lundbeck A/S, 2500 Valby, Denmark.

抄録

Erythropoietin (EPO) is both hematopoietic and tissue protective, putatively through interaction with different receptors. We generated receptor subtype–selective ligands allowing the separation of EPO's bioactivities at the cellular level and in animals. Carbamylated EPO (CEPO) or certain EPO mutants did not bind to the classical EPO receptor (EPOR) and did not show any hematopoietic activity in human cell signaling assays or upon chronic dosing in different animal species. Nevertheless, CEPO and various nonhematopoietic mutants were cytoprotective in vitro and conferred neuroprotection against stroke, spinal cord compression, diabetic neuropathy, and experimental autoimmune encephalomyelitis at a potency and efficacy comparable to EPO.

収録刊行物

• Science

  Science 305 (5681), 239-242, 2004-07-09

  American Association for the Advancement of Science (AAAS)

キーワード

• Multidisciplinary

詳細情報

• CRID: 1363670319708328832
• NII論文ID: 80016847950
• DOI: 10.1126/science.1098313
• ISSN: 10959203
• ISSN: 00368075
• Web Site: https://www.science.org/doi/pdf/10.1126/science.1098313
• データソース種別:
  • Crossref
  • CiNii Articles