Molecular signature associated with plasticity of bone marrow cell under persistent liver damage by self‐organizing‐map‐based gene expression

• Kaoru Omori

• Shuji Terai

• Tsuyoshi Ishikawa

• Kouji Aoyama

• Isao Sakaida

• Hiroshi Nishina

• Koh Shinoda

• Shunji Uchimura

• Yoshihiko Hamamoto

• Kiwamu Okita

抄録

The mechanism that regulates the plasticity of bone marrow cells (BMCs) into hepatocytes is poorly understood. We developed a green fluorescent protein/carbon tetrachloride model to find that BMC transplantation recovered liver damage. Serum albumin level and liver fibrosis were recovered by BMC transplantation. To understand the mechanism, we used DNA‐chip technology to profile the change of transient gene expression before and after BMC transplantation. On the basis of gene expression with self‐organizing map using specific equation, genes were classified into 153 clusters. The information is useful to understand the dramatic gene activation during the process of the plasticity of BMC.

収録刊行物

• FEBS Letters

  FEBS Letters 578 (1-2), 10-20, 2004-11-02

  Wiley

キーワード

• Cell Biology
• Genetics
• Molecular Biology
• Biochemistry
• Structural Biology
• Biophysics

詳細情報

• CRID: 1363670319601292800
• NII論文ID: 80017028847
• DOI: 10.1016/j.febslet.2004.09.090
• ISSN: 18733468
• ISSN: 00145793
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2Fj.febslet.2004.09.090
• Web Site: https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/j.febslet.2004.09.090
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