Regulation of human immunodeficiency virus 1 transcription by nef microRNA

DOI Web Site 被引用文献3件
  • Shinya Omoto
    Molecular Biology and Retroviral Genetics Group, Division of Nutritional Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan
  • Yoichi R. Fujii
    Molecular Biology and Retroviral Genetics Group, Division of Nutritional Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan

抄録

<jats:p>MicroRNAs (miRNAs) are ∼21–25 nt long and interact with mRNAs to lead to either translational repression or RNA cleavage through RNA interference. A previous study showed that human immunodeficiency virus 1 (HIV-1) <jats:italic>nef</jats:italic> dsRNA from AIDS patients who are long-term non-progressors inhibited HIV-1 transcription. In the study reported here, <jats:italic>nef</jats:italic>-derived miRNAs in HIV-1-infected and <jats:italic>nef</jats:italic> transduced cells were identified, and showed that HIV-1 transcription was suppressed by <jats:italic>nef</jats:italic>-expressing miRNA, miR-N367, in human T cells. The miR-N367 could reduce HIV-1 LTR promoter activity through the negative responsive element of the U3 region in the 5′-LTR. Therefore, <jats:italic>nef</jats:italic> miRNA produced in HIV-1-infected cells may downregulate HIV-1 transcription through both a post-transcriptional pathway and a transcriptional neo-pathway.</jats:p>

収録刊行物

被引用文献 (3)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ