Class III Homeodomain-Leucine Zipper Gene Family Members Have Overlapping, Antagonistic, and Distinct Roles in Arabidopsis Development

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  • Michael J. Prigge
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109-1048
  • Denichiro Otsuga
    Department of Biology, University of Utah, Salt Lake City, Utah 84112-0840
  • José M. Alonso
    Plant Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037
  • Joseph R. Ecker
    Plant Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037
  • Gary N. Drews
    Department of Biology, University of Utah, Salt Lake City, Utah 84112-0840
  • Steven E. Clark
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109-1048

Abstract

<jats:title>Abstract</jats:title><jats:p>The Arabidopsis thaliana genome contains five class III homeodomain-leucine zipper genes. We have isolated loss-of-function alleles for each family member for use in genetic analysis. This gene family regulates apical embryo patterning, embryonic shoot meristem formation, organ polarity, vascular development, and meristem function. Genetic analyses revealed a complex pattern of overlapping functions, some of which are not readily inferred by phylogenetic relationships or by gene expression patterns. The PHABULOSA and PHAVOLUTA genes perform overlapping functions with REVOLUTA, whereas the PHABULOSA, PHAVOLUTA, and CORONA/ATHB15 genes perform overlapping functions distinct from REVOLUTA. Furthermore, ATHB8 and CORONA encode functions that are both antagonistic to those of REVOLUTA within certain tissues and overlapping with REVOLUTA in other tissues. Differences in expression patterns explain some of these genetic interactions, whereas other interactions are likely attributable to differences in protein function as indicated by cross-complementation studies.</jats:p>

Journal

  • The Plant Cell

    The Plant Cell 17 (1), 61-76, 2005-01-01

    Oxford University Press (OUP)

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