Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice

DOI Web Site 被引用文献51件
  • Brian J. Cummings
    Departments of Physical Medicine and Rehabilitation and Anatomy and Neurobiology and Reeve-Irvine Research Center, University of California, Irvine, CA 92697; StemCells, Inc., 3155 Porter Drive, Palo Alto, CA 94304; and The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037
  • Nobuko Uchida
    Departments of Physical Medicine and Rehabilitation and Anatomy and Neurobiology and Reeve-Irvine Research Center, University of California, Irvine, CA 92697; StemCells, Inc., 3155 Porter Drive, Palo Alto, CA 94304; and The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037
  • Stanley J. Tamaki
    Departments of Physical Medicine and Rehabilitation and Anatomy and Neurobiology and Reeve-Irvine Research Center, University of California, Irvine, CA 92697; StemCells, Inc., 3155 Porter Drive, Palo Alto, CA 94304; and The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037
  • Desirée L. Salazar
    Departments of Physical Medicine and Rehabilitation and Anatomy and Neurobiology and Reeve-Irvine Research Center, University of California, Irvine, CA 92697; StemCells, Inc., 3155 Porter Drive, Palo Alto, CA 94304; and The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037
  • Mitra Hooshmand
    Departments of Physical Medicine and Rehabilitation and Anatomy and Neurobiology and Reeve-Irvine Research Center, University of California, Irvine, CA 92697; StemCells, Inc., 3155 Porter Drive, Palo Alto, CA 94304; and The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037
  • Robert Summers
    Departments of Physical Medicine and Rehabilitation and Anatomy and Neurobiology and Reeve-Irvine Research Center, University of California, Irvine, CA 92697; StemCells, Inc., 3155 Porter Drive, Palo Alto, CA 94304; and The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037
  • Fred H. Gage
    Departments of Physical Medicine and Rehabilitation and Anatomy and Neurobiology and Reeve-Irvine Research Center, University of California, Irvine, CA 92697; StemCells, Inc., 3155 Porter Drive, Palo Alto, CA 94304; and The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037
  • Aileen J. Anderson
    Departments of Physical Medicine and Rehabilitation and Anatomy and Neurobiology and Reeve-Irvine Research Center, University of California, Irvine, CA 92697; StemCells, Inc., 3155 Porter Drive, Palo Alto, CA 94304; and The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037

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<jats:p> We report that prospectively isolated, human CNS stem cells grown as neurospheres (hCNS-SCns) survive, migrate, and express differentiation markers for neurons and oligodendrocytes after long-term engraftment in spinal cord-injured NOD- <jats:italic>scid</jats:italic> mice. hCNS-SCns engraftment was associated with locomotor recovery, an observation that was abolished by selective ablation of engrafted cells by diphtheria toxin. Remyelination by hCNS-SCns was found in both the spinal cord injury NOD- <jats:italic>scid</jats:italic> model and myelin-deficient <jats:italic>shiverer</jats:italic> mice. Moreover, electron microscopic evidence consistent with synapse formation between hCNS-SCns and mouse host neurons was observed. Glial fibrillary acidic protein-positive astrocytic differentiation was rare, and hCNS-SCns did not appear to contribute to the scar. These data suggest that hCNS-SCns may possess therapeutic potential for CNS injury and disease. </jats:p>

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