Analysis of the full-length genome of hepatitis E virus isolates obtained from wild boars in Japan

• Tsutomu Nishizawa

  Division of Virology, Department of Infection and Immunity, Jichi Medical School, Tochigi-Ken 329-0498, Japan

• Masaharu Takahashi

  Division of Virology, Department of Infection and Immunity, Jichi Medical School, Tochigi-Ken 329-0498, Japan

• Kazunori Endo

  Division of Virology, Department of Infection and Immunity, Jichi Medical School, Tochigi-Ken 329-0498, Japan

• Shinji Fujiwara

  Koyadairamura Kokuho Clinic, Tokushima-Ken 777-0302, Japan

• Nobuo Sakuma

  Kawakamimura Kokuho Clinic, Yamaguchi-Ken 758-0122, Japan

• Fumiaki Kawazuma

  Yodakubo Hospital, Nagano-Ken 386-0603, Japan

• Hirotsugu Sakamoto

  Kitaibaraki Municipal General Hospital, Ibaraki-Ken 319-1704, Japan

• Yukihiro Sato

  Kamiichi General Hospital, Toyama-Ken 930-0391, Japan

• Masashi Bando

  Division of Pulmonary Medicine, Department of Medicine, Jichi Medical School, Tochigi-Ken 329-0498, Japan

• Hiroaki Okamoto

  Division of Virology, Department of Infection and Immunity, Jichi Medical School, Tochigi-Ken 329-0498, Japan

抄録

Two (2·3 %) of 87 wild-caught boars in Japan had detectable hepatitis E virus (HEV) RNA. The two boar HEV isolates (wbJTS1 and wbJYG1) obtained in the present study and a previously reported isolate (wbJSG1) whose partial sequence had been determined were sequenced over the entire genome. The wbJSG1, wbJTS1 and wbJYG1 isolates comprised 7225 or 7226 nt, excluding the poly(A) tail, and segregated into genotype 3. They differed by 8·5–11·2 % from each other and by 8·6–18·4 % from 17 reported genotype 3 HEV isolates, including one boar isolate, in the full-length sequence. When compared with 191 reported genotype 3 HEV isolates whose partial sequences were known, these three boar isolates were closer to Japanese isolates than to isolates of non-Japanese origin (89·2±2·6 vs 85·9±2·2 %; P <0·0001). A proportion of wild boars in Japan are infected with markedly heterogeneous HEV strains that are indigenous to Japan and may serve as reservoirs of HEV.

収録刊行物

• Journal of General Virology

  Journal of General Virology 86 (12), 3321-3326, 2005-12-01

  Microbiology Society

キーワード

• Virology

詳細情報

• CRID: 1361981469771096576
• NII論文ID: 80017632479
• DOI: 10.1099/vir.0.81394-0
• ISSN: 14652099
• ISSN: 00221317
• ISSN: http://id.crossref.org/issn/00221317
• Web Site: https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.81394-0?crawler=true
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