肝細胞癌のイヌに認められた耐熱性アルカリフォスファターゼアイソザイム

DOI 日本農学文献記事索引 Web Site Web Site PubMed 被引用文献2件 参考文献30件
  • FUKUI Yu-ichi
    Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
  • SATO Jun
    Department of Veterinary Medicine, Faculty of Agriculture, Iwate University Tomizawa Animal Hospital
  • SATO Reeko
    Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
  • YASUDA Jun
    Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
  • NAITO Yoshihisa
    Department of Veterinary Medicine, Faculty of Agriculture, Iwate University

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タイトル別名
  • Canine Serum Thermostable Alkaline Phosphatase Isoenzyme From a Dog With Hepatocellular Carcinoma

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A dog histopathologically diagnosed with hepatocellular carcinoma (HCC) showed very high serum alkaline phosphatase (ALP) activity. A supernatant of ascitic fluid and tumor tissue extracted from the dog also showed much higher ALP activity than normal. ALP isoenzyme analysis of samples was perfomed using polyacrylamide gel disk electrophoresis, and a wide, broad abnormal band was observed. By various treatments, the abnormal band showed thermostability, which is a characteristic of tumor-associated ALP that has only been reported in humans. The thermostable ALP isoenzyme was not found in sera from 39 dogs with several types of tumor that originated from the liver, except for HCC, nor was it found in 10 dogs with hepatic diseases that did not include hepatic tumors. The thermostable ALP isoenzyme seemed to be associated with canine HCC.<br>

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