AXR4 Is Required for Localization of the Auxin Influx Facilitator AUX1

DOI Web Site 被引用文献3件
  • S. Dharmasiri
    Department of Biology, Indiana University, Bloomington, IN 47405, USA.
  • R. Swarup
    Department of Biology, Indiana University, Bloomington, IN 47405, USA.
  • K. Mockaitis
    Department of Biology, Indiana University, Bloomington, IN 47405, USA.
  • N. Dharmasiri
    Department of Biology, Indiana University, Bloomington, IN 47405, USA.
  • S. K. Singh
    Department of Biology, Indiana University, Bloomington, IN 47405, USA.
  • M. Kowalchyk
    Department of Biology, Indiana University, Bloomington, IN 47405, USA.
  • A. Marchant
    Department of Biology, Indiana University, Bloomington, IN 47405, USA.
  • S. Mills
    Department of Biology, Indiana University, Bloomington, IN 47405, USA.
  • G. Sandberg
    Department of Biology, Indiana University, Bloomington, IN 47405, USA.
  • M. J. Bennett
    Department of Biology, Indiana University, Bloomington, IN 47405, USA.
  • M. Estelle
    Department of Biology, Indiana University, Bloomington, IN 47405, USA.

抄録

<jats:p> The AUX1 and PIN auxin influx and efflux facilitators are key regulators of root growth and development. For root gravitropism to occur, AUX1 and PIN2 must transport auxin via the lateral root cap to elongating epidermal cells. Genetic studies suggest that AXR4 functions in the same pathway as AUX1. Here we show that AXR4 is a previously unidentified accessory protein of the endoplasmic reticulum (ER) that regulates localization of AUX1 but not of PIN proteins. Loss of AXR4 resulted in abnormal accumulation of AUX1 in the ER of epidermal cells, indicating that the <jats:italic>axr4</jats:italic> agravitropic phenotype is caused by defective AUX1 trafficking in the root epidermis. </jats:p>

収録刊行物

  • Science

    Science 312 (5777), 1218-1220, 2006-05-26

    American Association for the Advancement of Science (AAAS)

被引用文献 (3)*注記

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