Synthesis of pyrrolidine-based oxy-peptide nucleic acids carrying four types of nucleobases and their transport into cytoplasm

• KITAMATSU M.

抄録

We synthesized 16 pyrrolidine-based oxy-peptide nucleic acid (POPNA) monomers carrying four different nucleobases onto four different stereoisomers of pyrrolidine rings. Using these monomers, we prepared POPNA oligomers, which formed sequence-specific hybrids with DNAs. The oligomer configurations influenced the hybrid stability. The oligomers were not taken into CHO cells. However, they could enter the cell cytoplasm when mixed with the influenza virus hemagglutinin peptide-arginine heptamer conjugate.

収録刊行物

• Tetrahedron

  Tetrahedron 66 (51), 9659-9666, 2010-12-18

  Pergamon-Elsevier Science Ltd.

キーワード

• Peptide nucleic acid
• Solid-phase peptide synthesis
• Cell-penetrating peptide
• Confocal laser scanning microscopy

詳細情報

• CRID: 1571698601428963200
• NII論文ID: 80021459911
• NII書誌ID: AA00861787
• ISSN: 00404020
• Web Site: http://ousar.lib.okayama-u.ac.jp/46941
• 本文言語コード: en
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