Structure of the measles virus hemagglutinin bound to its cellular receptor SLAM
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Measles virus, a major cause of childhood morbidity and mortality worldwide, predominantly infects immune cells using signaling lymphocyte activation molecule (SLAM) as a cellular receptor. Here we present crystal structures of measles virus hemagglutinin (MV-H), the receptor-binding glycoprotein, in complex with SLAM. The MV-H head domain binds to a b-sheet of the membrane-distal ectodomain of SLAM using the side of its b-propeller fold. This is distinct from attachment proteins of other paramyxoviruses that bind receptors using the top of their b-propeller. The structure provides templates for antiviral drug design, an explanation for the effectiveness of the measles virus vaccine, and a model of the homophilic SLAM-SLAM interaction involved in immune modulations. Notably, the crystal structures obtained show two forms of the MV-H–SLAM tetrameric assembly (dimer of dimers), which may have implications for the mechanism of fusion triggering.
収録刊行物
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- Nature Structural & Molecular Biology
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Nature Structural & Molecular Biology 18 (2), 135-141, 2011-02
Nature Pablishing Group
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詳細情報 詳細情報について
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- CRID
- 1571135651475567488
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- NII論文ID
- 80021640608
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- NII書誌ID
- AA10987726
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- ISSN
- 10728368
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- Web Site
- http://hdl.handle.net/2324/19802
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles
- KAKEN
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