Molecular cell genetics

Author(s)

• Gottesman, Michael M.

Bibliographic Information

Molecular cell genetics

edited by Michael M. Gottesman

Wiley, c1985

Note

"A Wiley-Interscience Publication."

Includes index

Description and Table of Contents

Description

Molecular Cell Genetics is the synthesis of somatic cell genetics with molecular biology. This volume focuses on the major role that Chinese hamster cell lines have had in the development of this new biological discipline. This volume will examine a wide variety of genetic systems developed in Chinese hamster cells. Each of the authors addresses the rationale for development of these systems, the details of mutant isolation and analysis, the major conclusions derived from these genetic studies, and where possible, the molecular basis for the expression of mutant phenotypes. Comparison is made with genetic analysis developed in non-Chinese hamster cell systems, so that the reader has an overview of the state of knowledge for each genetic locus.

Table of Contents

• THE DEVELOPMENT AND CHARACTERIZATION OF CHINESE HAMSTER CELL LINES: The Biology and Genetics of the Chinese Hamster
• Development of the Chinese Hamster Ovary (CHO) Cell for Use in Somatic Cell Genetics
• The Establishment of the V79 Chinese Hamster Lung Cell Line
• The Development and Use of the Chinese Hamster Embryo Fibroblast (CHEF) Cell Line
• The Genetic Map of the Chinese Hamster and the Genetic Consequences of Chromosomal Rearrangements in CHO Cells
• GENETIC MANIPULATION OF CHINESE HAMSTER CELLS: Growth Properties of Chinese Hamster Ovary (CHO) Cells
• Cell Fusion and Chromosome Sorting
• DNA-Mediated Gene Transfer
• Vector-Mediated Gene Transfer
• Cloning and Expression of cDNAs
• GENETIC SYSTEMS DEVELOPED IN CHINESE HAMSTER CELL LINES: Intermediary Metabolism: De novo Purine and Pyrimidine Biosynthesis
• The APRT System
• The HGPRT System
• Chinese Hamster Cell Protein Synthesis Mutants
• RNA Polymerases
• The Dihydrofolate Reductase Locus
• Regulation and Amplification of Asparagine Synthetase
• Chinese Hamster Cell Mutants with Altered Levels of Ornithine Decarboxylase: Overproducers and Null Mutants
• Mitochondrial Mutants
• CELL STRUCTURE AND BEHAVIOR: Cell Cycle Mutants
• DNA Repair Mutants
• Microtubule Mutants
• Genetics of Cyclic-AMP-Dependent Protein Kinases
• Lectin- Resistant Glycosylation Mutants
• Multidrug-Resistant Mutants
• Using Chinese Hamster Cells to Study Malignant Transformation
• Genetic Studies of Transformation and Tumorigenesis in Chinese Hamster Embryo Fibroblasts
• MECHANISM OF GENETIC VARIATION: Segregationlike Events in Chinese Hamster Cells
• Mechanisms of Genetic Variation in Chinese Hamster Ovary Cells
• Appendixes
• Index. .pa

by "Nielsen BookData"

Details

• NCID: BA0031327X
• ISBN:
  • 0471879258
• LCCN: 84021007
• Country Code: us
• Title Language Code: eng
• Text Language Code: eng
• Place of Publication: New York
• Pages/Volumes: xvi, 931 p.
• Size: 24 cm
• Classification:
  • LCC : QH430
  • DC19 : 574.87/322
• Subject Headings:
  • LCSH : Molecular genetics
  • LCSH : Cytogenetics