As data is accumulated life-style characteristics are shown to be major determinates of cancer risk in humans. Of these, diet is the most ubiquitous. Food constituents have been identified which can cause or enhance the likelihood of cancer and, conversely, protect against it. Such data encourage the hope that a full understanding of the impact of dietary constituents on carcinogenesis will lead to important means of cancer control. This international symposium coincided with an increasing awareness of the major impact diet can have on the occurrence of cancer, and at a time when the evaluation of existing data was critical for developing approaches to a complicated and important area of cancer research. The participating scientists represented a variety of disciplines ranging from epidemiology to molecular biology and the papers cover a diversity of subjects to provide a valuable state-of-the-art review of this topic. The presentations give rise to a sense of cautious optimism that future productive research on the relationship between diet, nutrition and cancer is feasible, and could result in the development of useful strategies for cancer prevention.
Preface Contributors Opening Address LECTURES Diet and nutrition as risk factors for cancer G.N. Wogan Application of the mechanisms of nutritional carcinogenesis to the prevention of cancer J.H. Weisburger EPIDEMIOLOGICAL STUDIES ON IMMIGRANT Multiethnic studies of diet, nutrition and cancer in Hawaii L.N. Kononel, J.H. Hankin and A.M.Y. Nomura A large scale cohort study on cancer risk by diet --- with special reference to the risk reducing effects of green-yellow vegetable consumption T. Hirayama MUTAGENS/CARCINOGENS IN FOODS Cancer risks posed by Aflatoxin M1 D.P.H. Hsieh, J.M. Cullen, L.S. Hsieh, Y. Shao and B.H. Ruebner Diet and exposure to N-Nitroso compounds S.R. Tannenbaum Nitrosatable precursors of mutagens in vegetables and soy sauce M. Nagao, K. Wakabayashi, Y. Fujita, T. Tahira, M. Ochiai, S. Takayama and T. Sugimura Effects of meat composition and conditions on the formation of mutagenic imidazoquinoxalines (MeIQx and its methyl derivatives) M. Jagerstad, A.L. Reutersward, S. Grivas, K. Olsson, C. Negishi and S. Sato Carcinogenicities in mice and rats of IQ, MeIQ and MeIQx H. Ohgaki, H. Hasegawa, T. Kato, M. Suenaga, S. Sato, S. Takayama and T. Sugimura Mutagenic nitropyrenes in foods Y. Ohnishi, T. Kinouchi, H. Tsutsui, M. Uejima and K. Nishifuji Occurrence and detection of natural mutagens and modifying factors in food products J.C.M van der Hoeven Human carcinogenic risk in the use of bracken fern I. Hirono MODULATION OF CARCINOGENESIS BY DIETARY COMPONENTS IN EXPERIMENTAL ANIMALS Suppression of carcinogenesis by retinoids: interactions with peptide growth factors and their receptors as a key mechanism M.B. Sporn and A.B. Roberts Significance of L-Ascorbic acid and urinary elecrolytes in promotion of rat bladder carcinogenesis S. Fukushima, T. Shirai, M. Hirose and N. Ito Enhancing effects of dietary salt on both initiation and promotion stages of rat gastric carcinogenesis M. Takahashi and R. Hasegawa Non-starch polysaccharides as a protective factor in human large bowel cancer S.A. Bingham Inhibition of carcinogenesis by some minor dietary constituents L.W. Wattenberg, A.B. Hanley, G. Barany, V.L. Sparnins, L.K.T. Lam and G.R. Fenwick The role of nutrients in cancer causation P.M. Newberne and A.E. Rogers CANCER EPIDEMIOLOGY ON MUTAGENS/CARCINOGENS IN FOODS Measurement of individual aflatoxin exposure among people having different risk to primary hepatocellular carcinoma T. Sun, S. Wu, Y. Wu and Y. Chu Vitamin A and Selenium intake in relation to human cancer risk W. Willett Dietary fibre in the Japanese diet M. Kuratsune, T. Honda, H.N. Englyst and J.H. Cummings Dietary fat in relation to mammary carcinogenesis K.K. Carroll Cancer risk in relation to fat and energy intake among Hawaii Japanese: a prospective G.N. Stemmermann, A.M.Y. Nomura and L.K. Heilbrun Dietary influences upon colon carcinogenesis A.J. McMichael and J.D. Potter The effect of calcium on the pathogenicity of high fat diets to the colon W.R. Bruce, R.P. Bird and J.J. Rafter Risk evaluation of tumor-inducing substances in foods T. Hayashi, Y. Kurokawa and A. Maekawa Cancer, diet and public policy S.A. Miller and F.E. Scarbrough CONCLUDING REMARKS AND FUTURE PERSPECTIVES Diet, nutrition and cancer: concluding remarks and future perspectives L. Tomatis Author index Subject index
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