Biology of proteoglycans

著者

• Mecham, Robert P.
• Wight, Thomas N.

書誌事項

Biology of proteoglycans

edited by Thomas N. Wight, Robert P. Mecham

（Biology of extracellular matrix, A series）

Academic Press, 1987

注記

Includes bibliographies and index

内容説明・目次

内容説明

Biology of Proteoglycans provides a representative, but by no means inclusive, sample of current research on the role of proteoglycans in the cell biology of the extracellular matrix. The book is organized into four areas: methodological developments; proteoglycan metabolism; proteoglycans in cartilage; and proteoglycans in "soft" tissues. It begins with discussions of current methodological developments which have had enormous impact on understanding the complexity of proteoglycan structure. These include the use of monoclonal antibodies to probe the structure of the protein and carbohydrate portions of proteoglycans; and studies on the genes that code for the proteoglycan protein cores and associated proteins. This is followed by separate chapters on various aspects of proteoglycan metabolism, including the synthetic pathway used by cells to synthesize proteoglycans containing heparin and heparan sulfate; the molecular organization of different proteoglycans in cartilage; the role of proteoglycans and associated proteins in the calcification process in growth plate; and the emerging field of proteoglycans in "soft" or noncartilagenous tissue.

目次

Preface Monoclonal Antibodies as Probes for Elucidating Proteoglycan Structure and Function I. Introduction II. Production, Screening, and Characterization of Monoclonal Antibodies Directed against Epitopes Present on Proteoglycan Substructures III. Monoclonal Antibodies to Epitopes Present on Proteoglycan Monomers IV. Monoclonal Antibodies to the Link Proteins of Cartilage Proteoglycan Aggregate V. General Discussion References Molecular Biology of Proteoglycans and Link Proteins I. Perspectives IL Cell-Free Translation of mRNAs Encoding Proteoglycan Core Proteins and Link Proteins III. Cloning of Proteoglycan Core Protein and Link Protein cDNAs IV. Prospectives References Biosynthesis of Heparin and Heparan Sulfate I. Introduction II. The Proteoglycans-Structures and Interactions III. Outline of the Biosynthetic Process IV. Regulation of Polymer Modification V. Organization of the Biosynthetic Apparatus VI. Perspectives for the Future References Proteoglycan Metabolism by Rat Ovarian Granulosa Cells In Vitro I. Introduction II. Characterization of Granulosa Cell Proteoglycans III. Metabolism of Granulosa Cell Proteoglycans IV. General Considerations References Integral Membrane Proteoglycans as Matrix Receptors: Role in Cytoskeleton and Matrix Assembly at the Epithelial Cell Surface I. Introduction II. Characteristics of Mammary Epithelial Cell Surface Proteoglycan III. Distribution of Epithelial Cell Surface Proteoglycan IV. Heparan Sulfate Proteoglycan Binds Stromal Matrix Components V. Cell Surface Proteoglycan as a Matrix Anchor to the Cytoskeleton VI. Cell Surface Proteoglycan is a Matrix Receptor VII. Summary References Structural Organization of Proteoglycans in Cartilage I. Introduction II. Macromolecular Structure of Isolated Proteoglycans Based on Electron-Microscopic Analysis III. Preservation Methods for Proteoglycans in Tissue IV. Morphology of Proteoglycans in Cartilage V. Spatial Arrangement of Proteoglycans in Native Tissue References Proteoglycans, Chondrocalcin, and the Calcification of Cartilage Matrix in Endochondrial Ossification I. Anatomical Organization of the Growth Plate II. Composition and Organization of the Cartilage Matrix of Growth Plate III. Changes in the Proteoglycans of the Growth Plate Associated with Calcification IV. Purified Proteoglycans and Glycosaminoglycans Can Bind Calcium and Inhibit Calcification In Vitro V. A Unifying Hypothesis to Explain the Proteoglycan Changes That May Occur in Calcifying Growth Plate Cartilage References Biochemical Basis of Age-Related Changes in Proteoglycans I. Introduction II. Aging and Maturation III. Proteoglycan Populations: Age-Related Changes IV. Biosynthesis V. Proteoglycans in Disease References Extracellular Matrix Components of the Synapse I. Introduction II. ECM Components are Involved in Synaptic Regeneration III. Axonal Transport of Sulfated Materials IV. Proteoglycans in Secretory Vesicles V. A Synaptic Junctional Proteoglycan Related to the Vesicle Form VI. Purification and Characterization of the ECM Proteoglycan VII. The Antigenic Determinant of Electric Organ TAP VIII. Insertion of the Anchorage Protein IX. Other Components of the ECM at the Synapse References Blood Vessel Proteoglycans I. Introduction II. Biochemistry of Arterial Proteoglycans III. Morphology of Arterial Proteoglycans IV. Proteoglycans in Atherosclerosis V. Cell Culture Studies VI. Concluding Remarks References Heparan Sulfate Species and Blood Vessel Wall Function I. Introduction II. The Role of Heparan Sulfate Species as a Regulator of Coagulation Mechanism Activity III. Role of Heparan Sulfate as a Modulator of Smooth Muscle Proliferation References Cell-Associated Proteoglycans in Human Malignant Melanoma I. Extracellular Matrix Composition during Tumorigenesis II. Chondroitin Sulfate Proteoglycans Synthesized by Human Melanoma Cells: Production of Monoclonal Antibodies III. Biosynthesis and Intracellular Transport of Proteoglycans IV. Conclusion References Intracellular Proteoglycans in Cells of the Immune System I. Introduction II. Localization and Characterization of Secretory Granule Proteoglycans in Different Cell Types III. Speculated Functions of Intracellular Proteoglycans in Immunity and Inflammation IV. Summary References Index

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詳細情報

• NII書誌ID(NCID): BA00988094
• ISBN:
  • 0127506500
• LCCN: 86026476
• 出版国コード: us
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: Orlando, Fla.
• ページ数/冊数: xiii, 400 p.
• 大きさ: 24 cm
• 分類:
  • LCC : QP552.P73
  • DC19 : 599/.019/2454
• 件名:
  • LCSH : Proteoglycans
• 親書誌ID:
  • BA00635913