Recently, considerable attention has been focused on studies of membrane structure and function--involvement of cell surface components in intercellular interaction, in translocation of ligands and receptors across cell membranes, and in the immunological properties of cells and gene expression and regulation. These investigations have led to the development of powerful technical tools which can be of immense value in the study of animal and human reproduction. The investigations of problems such as gamete interaction, fertilization, embryo implantation, and development have reached a stage where further meaningful progress in their understanding does not seem likely unless the conventional approaches are coupled with more modern molecular and cellular techniques. Furthermore, 1t is only through such basic studies that potential means of fertility regulation will emerge. The various physiological events in animal reproduction such as fertilization and implantation essentially involve an interaction between specific cell membrane components. Similarly, embryogenesis involves the expression and regulation of genes at various stages of development.
Therefore, the entire Workshop was specifically devoted to two topics: 1) Structure, function, and biosynthesis of membrane components, and 2) Gene expression and regulation as related to animal reproduction. The presentations relating to each topic are presented in separate sections in this book.
Membranes: Structure, Function, and Biosynthesis.- Characterization of Glycoproteins: Carbohydrate Structures of Glycoprotein Hormones.- Biosynthetic Controls that Determine the Branching and Microheterogeneity of Protein-Bound Oligosaccharides.- Mechanisms and Regulation of TSH Glycosylation.- Functional Adaptations of Transbilayer Proteins.- Characterization of a Sperm Membrane Glycoprotein.- Sperm Membrane and Zona Pellucida Interactions During Fertilization..- The Interaction of Egg Peptides with Spermatozoa.- The Role of Tyrosine Phosphorylation in the Regulation of Insulin and Insulin-Like Growth Factor-I Receptor Kinase Activities.- Internalization of Hormone Receptor Complexes: Route and Significance.- Gene Expression and Reproduction.- Chromatin Structure and Gene Expression in Germ Line and Somatic Cells.- Organization and Expression of Gonadotropin Genes.- Structure and Expression of Human Placental Hormone Genes.- Structure and Regulated Expression of Bovine Prolactin and Bovine Growth Hormone Genes.- The Use of Specific cDNA Probes to Assay Sertoli Cell Functions.- Mammalian Gene Transfer and Gene Expression.- Reversible Dissociation of Chick Oviduct Progesterone Receptor Subunits.- Contributors.
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