- 巻冊次
-
6 ISBN 9780444810618
内容説明
The Bone and Mineral Research series tradition of presenting up-to-date reviews of exciting research, both basic and clinical, is carried on in this, the sixth volume of the series. The main topics covered in this volume are the following: # the origin of the osteoclast - a thorough, critical review is provided # the multiplicity of peptides identified as local regulators of bone cell growth, specialization or both - reviewed # the discovery, characterization and biological significance of bone morphogenetic protein - described in detail # the impact of thyroid hormones on bone and mineral metabolism - timely review presented # the impact of mechanical forces on bone tissue - critically reviewed # an extensive study of hypophosphatasia, from genetic, clinical and mechanistic standpoints provided # aluminum-related disorders of bone and mineral metabolism - specific discussion presented, following on from the detailed review presented on renal osteodystrophy in Volume 5 # the biology of calcitonin and the regulation of its secretion by C cells - thorough discussion presented # predictive strategy on who will develop osteoporosis - thorough description of this development provided
目次
Editor's foreword (W.A. Peck). 1. The origin of the osteoclast (T.J. Chambers). 2. The regulation of bone formation by local growth factors (E. Canalis, T. McCarthy and M. Centrella). 3. Bone morphogenetic protein, bone regeneration, heterotopic ossification and the bone - bone marrow consortium (M.R. Urist). 4. Thyroid hormones and mineral metabolism (H.M. Perry III). 5. Mechanical forces and bone (E.L. Smith and C. Gilligan). 6. Alkaline phosphatase: physiological role explored in hypophosphatasia (M.P. Whyte). 7. Aluminum-related disorders of bone and mineral metabolism (T.J. Hahn). 8. Medullary thyroid carcinoma and calcitonin gene expression (L.J. Deftos and B.A. Roos). 9. Is it possible to predict the fast bone loser just after the menopause? (C. Christiansen and B.J. Riis). Subject index.
- 巻冊次
-
7 ISBN 9780444813718
内容説明
The aim in putting together this 7th volume of the Bone and Mineral Research series has been to present high quality, up-to-date reviews and in-depth analyses in areas where developments are, or potentially could be, of great interest to the Bone and Mineral research community. The high standard already established in the previous six volumes of this series (under direction of Dr. William A. Peck) has been maintained. There has een some astounding progress made within some areas of bone and mineral research, whereas in other areas a slow and gradual accumulation of knowledge has resulted in increased insight, so as well as including reviews in both areas, the chapters emphasize the development of new concepts. The chapter subjects covered are as follows:
目次
Editor's Foreword (J.N.M. Heersche and J.a. Kanis). 1. Extracellular calcium homeostasis (A.M Perault-Staub et al). 2. Calcium and hypertension (D.A. McCarron). 3. The pathogenesis of humoral hypercalcaemia of malignancy (S.H. Ralston). 4. Isolation, biochemistry and molecular biology of the PTH-related protein of malignant hypercalcemia (J.M. Moseley and L.J. Suva). 5. Osteogenesis imperfecta (D.W. Rowe). 6. Osteogenic stem cells in the bone marrow (A.J. Friedenstein). 7. Estrogens and bone (E.F. Eriksen and L. Mosekilde). 8. Vitamin D and the skin: photobiology, physiology and therapeutic efficacy for psoriasis (M.F. Holick). Subject index.
- 巻冊次
-
8 ISBN 9780444896599
内容説明
Although the regulation and mechanism of action of the major calcium regulating hormones (such as vitamin D and parathyroid hormone) have long been recognised, there are more important gaps in knowledge. This volume reviews the prevalence, patholophysiology and consequences of primary hyperparathyroidism, one of the most common endocrine disorders. It covers the potential role of vitamin D in disorders of proliferation, providing some thoughtful insights into the signals for parathyroid gland profileration and secretation, and making the important distinction between the two. The volume also contains contributions in the areas of: bone remodelling (including the cytokines and their regulation in physiology of bone call function, of bone disease; aspects of regulation of cartilage differentation and metabolism; and TGFB, one of the major non-collagenous cytokines in bone); the broad clinical classification of Sillience; and the bisphosphonates (including their use in Paget's disease, tumor induced bone disease, hyperpathyroidism and osteoporosis; and their structure, function, pharmacokinetic mechanism of action and the therapeutic implications.
目次
Primary Hyperparathyroidism: Prevalence, Pathophysiology, Pertinent Findings and Prognosis (S. Ljunghall, J. Rastad, G. Akerstrom). Vitamin D and Cancers: New insight into Vitamin D Physiology and Potential for Cancer therapy (J.A. Eisman). Cytokines and Cellular interactions in the control Bone of Remodelling (M.. Gowen). Regulation of Cartilage Differentiation and Metabolism (F. Suzuki). Transforming Growth Factor-bs: Biological Activities Related to bone Metabolism (D.M. Rosen). Osteogenesis Imperfecta as a Consequence of Naturally Occuring and induced Mutations of Type I Collagen (W.G. Cole). Bisphosphonates in Clinical Medicine (J.-P Bonjour, R, Rizzoli, P. Amman, T. Chevalley). Bisphosphonates and Therapeutic Implications (A.D. Geddes, S.M. D'Souza, F.H. Ebetino, K.J. Ibbotson).
「Nielsen BookData」 より