Immunogenicity : proceedings of a UCLA Symposium held at Steamboat Springs, Colorado, January 21-28, 1989
Author(s)
Bibliographic Information
Immunogenicity : proceedings of a UCLA Symposium held at Steamboat Springs, Colorado, January 21-28, 1989
(UCLA symposia on molecular and cellular biology, new ser.,
Wiley-Liss, c1990
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Includes bibliographical references
Description and Table of Contents
Description
A clear understanding of immunogenicity is necessary for the design of effective vaccines and the avoidance of unnatural immune responses. This study offers a thorough examination of the involved mechanisms of immunogenicity and its practical applications. It focuses on the events that lead to T-cell activation and memory generation, deals with the processing and presentation of antigens to T-cells, examines recognitive and signalling events and covers the processes surrounding lymphocyte activation. There is a full discussion of immunological memory and the role of immunogenicity in infectious diseases, vaccine design, transplantation immunity and autoimmunity.
Table of Contents
- Partial table of contents:
- ANTIGEN UPTAKE AND PROCESSING
- Where Do Antigens Associate with MHC Class I Molecules?
- (J. Yewdell, et al.)
- THE GENERATION OF AN IMMUNOGENIC LIGAND
- Effects of Peptide Competition on Antigen Presentation (L. Adorini, et al.)
- T CELL RECOGNITION OF ANTIGEN: MHC COMPLEXES
- The Role of CD4 in T Cell Activation (S. Goldman, et al.)
- TRANSMEMBRANE SIGNALING IN LYMPHOCYTES
- Regulation of Cytoplasmic Calcium Concentration in T Cells (J. Ledbetter, et al.)
- THE ROLE OF THE ANTIGEN PRESENTING CELL IN IMMUNOGENICITY
- Dendritic Cells: Nature's Adjuvant (R. Steinman, et al.)
- TOLERANCE: THE INACTIVATION OF LYMPHOCYTES BY SPECIFIC LIGAND
- Transgenic Model for Tissue Specific Antigens: Tolerance and Clonal Anergy (D. Lo, et al.)
- THE GENERATION AND PERSISTENCE OF IMMUNOLOGICAL MEMORY
- Immunological Memory: Longlived Cells or Longlived Antigen?
- (D. Gray)
- IMMUNOGENICITY IN DISEASE
- Workshop on Immunogenicity in Infectious Diseases (P. Doherty & S. Kaufmann)
- SYSTEMS QUESTIONS IN IMMUNOGENICITY
- Distinct Antigen Presenting Cells for Activation of Suppressor and Contrasuppressor T Cells (H. Braley-Mullen)
- Index.
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