Biochemistry of chemical carcinogenesis

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書誌事項

Biochemistry of chemical carcinogenesis

edited by R. Colin Garner and Jan Hradec

Plenum Press, c1989

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注記

"Proceedings of a satellite symposium of the Fourteenth International Congress of Biochemistry, on biochemistry of chemical carcinogenesis, held July 7-9, 1988, in Prague, Czechoslovakia"--T.p. verso

Includes bibliographical references

内容説明・目次

内容説明

The hepatocarcinogenicity of aflatoxin BI in rats, ducks and rainbow trout has been convincingly demonstrated (1). In contrast, adult mice appear to be resistant to the toxic and carcinogenic effects. Newborn and infant mice are more sensitive to the effects of different hepatocarcinogens (2,3) and also to AFB , which induced hepatomas in newborn C57BL/6 x C3H FI I mice (4). A singl~ dose model of aflatoxin hepatocarcinogenesis was tested in infant C57BL/6 mice. AFBI was administered i.p. on day 7 after birth and the following data were investigated: 1) Changes in the activities of microsomal cytochrome P-450 dependant enzymes and conjugating enzymes in the course of the 20-month-Iong aflatoxin hepa- tocarcinogenesis study. At intervals of 6,8,12,18 and 20 months a~ter AFBI administration, the concentrations of cyt P-450 andb and the acti- 5 vities of NADPH-, NADH-cyt c reductase, AOH, ADM, EH and GST were deter- mined. 2) Effect of continually administered diethyldithiocarbamate on the course of aflatoxin carcinogenesis. MATERIALS AND METHODS Aflatoxin BI was prepared biosynthetically in our laboratory and was checked for purity chromatographically, spectrophotometrically and by NMR.

目次

Chemical Carcinogenesis and the Primary Prevention of Human Cancer.- Metabolism of Chemical Carcinogens.- Mechanisms of Chemical Carcinogenesis.- Chemical Carcinogens Present in Nigerian (African) Foods and Drinks.- Conversion Induced by Transforming Growth Factors a and 8: The Role of "Wound Hormones" in Multistage Skin Carcinogenesis.- Arachidonic Acid Metabolites as Endogenous Mediators of Chromosomal Alterations and Tumor Development in Mouse Skin In Vivo.- Studies on the Mechanism of Conversion Effected by Tumor Promoter TPA.- Genotoxic Effect of Naturally Occurring and Cooked-Food-Related Mutagens.- Biochemistry of DNA Repair Patch Synthesis in UV-Irradiated Permeable Diploid Human Fibroblasts.- Interactions of Carcinogens with Nucleic Acids.- The Induction of Alkali Labile Sites in the DNA of CHO Cells by Methyl Methansulphonate and Dimethylsulfate and its Relationship to the Inhibition of Nascent DNA Chain Elongation.- Functional Significance of Ribonucleic Modified Acids by Chemical Carcinogens: A Review.- Evaluation of Carcinogenic and Non-Carcinogenic Metal Compounds by their Interference in the Renaturation of Highly Polymerized DNA and their Activation by Microsomes.- Chemical Carcinogens and Oncogenes.- Ras P21 Level and Tyrosine Kinase Activity During Carcinogenesis of Human Colon Tumors.- Utilization of Initiator Transfer Ribonucleic Acid Modified by Carcinogens Cholesteryl 14-Methylhexadecanoate and N-Methyl-N-Nitrosourea for Cell-Free Protein Synthesis.- Effect of Thiram on Cytochrome P-450 Studies by the CYPIA-Test.- Translocation of Phosphatidate Phosphohydrolase from the Cytosol to Microsomal Membranes is Increased in Experimental Liver Tumors.- Induction of Hepatoma in Seven-Day-Old C57L/6 Mice with a Single Dose of Aflatoxin and the Influence of Diethyldithiocarbamate.- Inhibition of Chemical Carcinogenesis.- Chemoprevention and Reduction of Cancer Risks Caused by Nitrosatable Drugs.- Influence of Dietary Constitutents in Chemical Carcinogenesis in Rats.- Liver Glutamate and Glutamine Concentration in Hepatocarcinogenesis Experimental: Effect of Glutathione.- Modification of Nitrosamine Carcinogenesis by Ascorbic Acid.- Genetic Damage in Peripheral Lymphocytes of Chronic Alcoholics.- Biochemical Markers of Cell Heterogeneity in Rat Mammary Tumors Induced by 7, 12-Dimethylbenzanthracene (DMBA) and N-Methyl-N-Nitrosourea (MNU).- Fate of Glutathione Related Enzyme Activities and In Vitro Lymphocyte Transformation in Patients with Bronchial Carcinoma.- Tumor Markers in Bronchioalveolar Lavage.- Phosphorylation Dephosphorylation of the Cytochrome P-450 - Dependent Monooxygenase System Regulatory Devices by Posttranslational Modification.- Effect of S-Adenosyl-L-Methionine on Serum Lipoprotein in Experimental Hepatic Carcinogenesis.

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