Natural resistance to tumors and viruses
著者
書誌事項
Natural resistance to tumors and viruses
（Current topics in microbiology and immunology, 92）
Springer-Verlag, 1981
- : gw
- : us
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注記
Includes bibliographies and index
内容説明・目次
内容説明
Natural resistance is now coming to be recognized as a potentially important phenomenon in host defense against infection and ma- lignancy. Genetically controlled resistance mechanisms are usUally effective early in infection and before conventional immune responses are generated. Comparisons of experimental systems where natural resistance plays a prominent role demon- strate the complexities of the host defense mechanisms involved, as evidenced in the present volume. Nevertheless, some com- mon components of genetic resistance are discernible and largely comprise natural killer cells, macrophages, and interferon These and additional factors would seem to constitute a first line of de- fense in host resistance against both viruses and tumors. It is evi- dent that considerable variation in the relative importance of di- stinct mechanisms may be found among various resistance sy- stems and that, most likely, additional effector functions will be discovered. Resistance to tumors and most viruses is under polygenic control, has a complex mode of inheritance, and depends on appro- priately complex effector mechanisms.
Instances, however, whe- re a single gene locus determines resistance or susceptibility to a virus, as in the case of resistance to flaviviruses or influenza viru- ses, would seem to offer good prospects for elucidating the basic factors involved. Resistance to influenza virus would indeed seem to represent a comparatively simple situation: resistance is expressed at the host cell level, and interferon is its main media- tor. The present volume provides insight into current concepts of such resistance mechanisms.
目次
Genetically Controlled Resistance to Flavivirus and Lactate-Dehydrogenase-Elevating Virus-Induced Disease.- Resistance to Herpes Simplex Virus - Type 1 (HSV-1).- Inborn Resistance of Mice to Orthomyxoviruses.- Role of Macrophages and Interferon in Natural Resistance to Mouse Hepatitis Virus Infection.- Genetic Resistance to Friend Virus-Induced Erythroleukemia and Immunosuppression.- Natural Cell-Mediated Immunity During Viral Infections.- Surveillance of Primitive Cells by Natural Killer Cells.- Indexed in Current Contents.
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