Regulation and functional significance of T-cell subsets
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書誌事項
Regulation and functional significance of T-cell subsets
（Chemical immunology, vol. 54）
Karger, c1992
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内容説明・目次
内容説明
This volume offers a review of T-cell heterogeneity in man and experimental animals and the implications of this heterogeneity for infectious and autoimmune diseases. It has recently become clear that peripheral T cells, both of the CD4+ and CD8+ lineages, can be divided into multiple subsets based on function, cytokine production and surface phenotype. Several articles describe the control of differentiation of these subsets and the phenotypic markers that correlate with specific functions and differentiation stages. Other articles discuss the participation of T-cell subsets in parasitic and mycobacterial diseases, AIDS and autoimmune disease. They describe some of the clearest examples of infectious and autoimmune diseases in which different clinical forms are the result of different T-cell subsets responding to the pathogen. The last article is an extensive review of the mechanisms of delayed-type hypersensitivity, the basic manifestation of cell-mediated immunity. Taken together, these articles provide a cellular and biochemical basis for T-cell regulation of the fundamental dichotomy in immunology - cell-medicated versus humoral immunity.
目次
- Programming of lymphocyte responses to activation - extrinsic factors, provided microenvironmentally, confer flexibility and compartmentalization to T-cell function, R.A. Daynes and B.A. Araneo
- T helper cell immune dysfunction in asymptomatic, HIV-1-seropositive individuals - the role of TH1-TH2 cross-regulation, G.M. Shearer and M. Clerici
- evidence for functional subsets of CD4+ and CD8+ T cells in human disease - lymphokine patterns in leprosy, P. Salgame, et al
- cell subsets in experimental allergic encephalomyelitis - interactions between the immune and neuroendocrine systems in the regulation of their activity, D. Mason
- postthymic differentiation of CD4 T lymphocytes - naive versus memory subsets and further specialization among memory cells, K.J. Horgan, et al
- murine CD4+ T-cell subsets generated by antigen-independent and dependent mechanisms, K. Kayakawa, et al
- induction, regulation and function of T-cell subsets in Leishmaniasis, F.Y. Liew
- biological role of helper T-cell subsets in Helminth infections, C.I. King and T.B. Nutman
- delayed-type hypersensitivity recruitment of T-cell subsets via antigen-specific non-IgE factors or IgE antibodies - relevance to asthma, autoimmunity and immune responses to tumours and parasites.
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