Central serotonin receptors and psychotropic drugs
著者
書誌事項
Central serotonin receptors and psychotropic drugs
（Frontiers in pharmacology & therapeutics）
Blackwell Scientific, 1992
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内容説明・目次
内容説明
This book critically reviews the present status of the evidence for multiple serotonin (5-HT) receptors in the brain and the prospects for the development of new drugs for the treatment of psychiatric disease based on an understanding of these receptor sub-types. The book does not cover in detail the clinical evidence of efficacy of existing compounds but rather future prospects for new drugs founded on basic studies in animals and man. The contributions are from leading scientists working in the area of serotonin research who are able to provide an unbiased and critical assessment of our present state of knowledge by means of concise and well referenced chapters. The book is directed towards research workers wishing to obtain either an introduction into central serotonin receptor research and their potential clinical importance or a critical evaluation of the current position.
目次
- Part I: Classification of 5-HT Receptor Subtypes in the Central Nervous System
- 5-HT receptor binding sites in the central nervous system and their distribution
- Neurochemical identification of 5-HT receptor subtypes
- Central 5-HT receptor subtypes: physiological responses and signal transduction mechanisms
- Pharmacological identification of 5-HT receptor subtypes using behavioural models
- 5-HT receptor distribution in the human brain: autoradiographic studies
- Brain 5-HT dysfunction in major psychiatric disorders
- Part II: 5HT Receptors and Drug Development
- Role of 5-HT receptors in behaviour
- 5-HT receptors in behaviour
- 5-HT receptors and anxiolytic drugs
- 5-HT receptors and antipsychotic drugs
- Effects of antidepressants on 5-HT neurotransmission
- 5-HT receptors and cognitive function
- 5-HT and ingestive behaviour
- 5-HT receptors and addiction
- Future directions - a summary
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