Molecular aspects of anticancer drug-DNA interactions

書誌事項

Molecular aspects of anticancer drug-DNA interactions

edited by Stephen Neidle and Michael Waring

(Topics in molecular and structural biology)

MacMillan, 1993-

  • v. 1
  • v. 2

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注記

Includes bibliographical references and index

内容説明・目次

巻冊次

v. 1 ISBN 9780333551158

内容説明

The Series provides researchers in the biological and medical sciences with timely reviews of selected areas in the molecular biology. Each volume is edited by an internationally recognised authority who selects authors and topics to provide a survey of current growth points in a specific field. Molecular Aspects of Anticancer Drug - DNA Interactions aims to be a definitive work in the cancer chemotherapy area replacing the editors previous book on anti-cancer drug design which though still widely quoted as the standard book in the field has now become rather out of date. Such is the wealth of important new material generated by the most prominent workers in the field that the Publishers have found it necessary to split the work text into two volumes. Volume two will be published later in the year.

目次

  • Selectivity in alkylating agent-DNA interactions, J.A. Hartley
  • structure-activity studies of anthracycline-DNA complexes, A.H.J. Wang
  • advances in the study of pyrrolo (2,1-c)(1,4) benzodiazepine (PBD) anti-tumour antibiotics, D.E. Thurston
  • molecular aspects of the interaction of (+)-CC-1065 with DNA, L.H. Hurley and P.H. Davies
  • molecular aspects of the platinum-DNA interactions, K.M. Comess and S.J. Lippard
  • new platinum drugs, M.J. McKeage and L.R. Kelland
  • echinomycin and related antibiotics, M.J. Waring
  • molecular basis of necarzinostatin action - roles of DNA microstructure and thiol in the mechanism of bi-stranded oxidative damage, L.H. Goldberg
  • anti-sense oligonucleotides as potential inhibitors of gene expression, D.M. Tidd
  • anti-gene nucleic acids inhibition of gene expression via triple helix formation, D.A. Collier
  • design of sequence-specific agents - lexitropsins, J.W. Lown.
巻冊次

v. 2 ISBN 9780333602386

内容説明

This series provides researchers in the biological and medical sciences with timely reviews of selected areas in the molecular biology. Each volume is edited by an internationally recognised authority who selects authors and topics to provide a survey of current growth points in a specific field. "Molecular Aspects of Anticancer Drug - DNA Interactions" aims to be a definitive work in the cancer chemotherapy area replacing the editors' previous book on anti-cancer drug design which though still widely quoted as the "standard work", in the field has now become rather out of date. Such is the wealth of important new material generated by prominent workers in this area, that the publishers have found it necessary to split the text text into two volumes. Volume one was published several months ago.

目次

  • DNA topoisomerases, K. Kohn and R. Ralph
  • the cellular and molecular pharmacology of the anthrapyrazole antitumour agent, D.R. Newell and L.H. Patterson
  • calicheamicin, G.A. Elistad and W.D. Ding
  • molecular pharmacology of intercalator - groove binder hybrid molecules, C. Bailly and J.P. Henichart
  • bleomycins - mechanism of polynucleotide recognition and oxidative degradation, A. Natrajan and S.M. Hecht
  • kinetic analysis of drug-nucleic acid binding modes - absolute rates and effects of salt concentration, W.D. Wilson and F.A. Tanions
  • acridine-based anti-cancer drugs, W.A. Denny and B.C. Baguley
  • the mitomycins - natural cross-linkers of DNA, M. Tomasz.

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