Diabetes : clinical science in practice

著者

書誌事項

Diabetes : clinical science in practice

edited by R.D.G. Leslie and David C. Robbins

Cambridge University Press, c1995

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注記

Includes index

内容説明・目次

内容説明

This significant new publication provides a summary and overview of the most recent scientific advances in diabetes research, and highlights the role of these developments in advancing clinical practice. Diabetes is one of the major causes of morbidity and mortality in the developed world, and its prevalence elsewhere is on the increase. It affects in excess of 100 million people worldwide. Recent scientific advances have clarified our understanding of the causes and consequences of this devastating disease. These scientific developments are playing an increasingly important role in clinical practice and could well lead the way to the prevention of complications and even a cure for the disease. An international and authoritative team of authors draws together this knowledge and the most recent developments to provide an up-to-date account which will benefit researchers and clinicians.

目次

  • 1. The regulation of insulin gene transcription
  • 2. Molecular structure of insulin
  • 3. Regulation of insulin secretion
  • 4. Insulin receptors
  • 5. The role of protein phosphorylation in insulin action
  • 6. Glucose transport mechanisms
  • 7. Glucose homeostasis
  • 8. Epidemiology of insulin-dependent diabetes mellitus (IDDM)
  • 9. Genetics of IDDM
  • 10. Aetiology of Type 1 (insulin-dependent) diabetes
  • 11. Epidemiology of NIDDM
  • 12. Genetic basis of the aetiology of non-insulin-dependent diabetes (NIDD)
  • 13. Islet amyloid polypeptide and amyloid in the islets of Langerhans
  • 14. Primary insulin resistance
  • 15. Epidemiology of the complications of diabetes
  • 16. Macrovascular disease in diabetes
  • 17. Diabetic neuropathy
  • 18. Diabetic foot infections
  • 19. Ocular complications of diabetes
  • 20. Diabetic nephropathy
  • 21. The personal, social and economic burden of diabetic complications
  • 22. Mortality among persons with diabetes
  • 23. Glycation and diabetic complications
  • 24. The sorbitol pathway and diabetic complications
  • 25. Proteinuria and diabetic complications
  • 26. Pharmacologic approaches to NIDDM
  • 27. Insulin and insulin analogues
  • 28. Hypoglycaemia
  • 29. Strategies for prevention of Type 1 (insulin-dependent) diabetes
  • 30. Treatment of early diabetic renal disease
  • 31. Pancreatic transplantation in humans with diabetes mellitus
  • 32. Rational insulin management of IDDM
  • 33. Rationale in the management of non-insulin-dependent diabetes mellitus (NIDDM)
  • 34. Psychosocial aspects of diabetes care
  • Index.

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