Excitatory amino acids and the cerebral cortex
著者
書誌事項
Excitatory amino acids and the cerebral cortex
（Bradford book）
MIT Press, c1996
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注記
Includes bibliographical references (p. [375]-466) and index
内容説明・目次
内容説明
The thirty original contributions in this book provide an up-to-date, interdisciplinary account of current research activity in all aspects of excitatory amino acid transmitters, particularly glutamate and aspartate, in the context of the structure and function of the cerebral cortex in health and in disease. It has recently become clear that the excitatory amino acids and their receptors are critically linked to normal processes of development and synaptic transmission, and to learning and memory, as well as to identifiable disease processes such as Alzheimer's disease, epilepsy, and cortical damage due to stroke/ischemia. Moreover, the pharmacological nature and chemical structures of many of the receptors and binding sites for these synaptic mediators and their modulators are becoming known, thereby enabling the cloning of each receptor subtype. Such advances may help immeasurably in the identification of endogenous ligands for the amino acid receptors and the development of pharmaceuticals and other therapeutic interventions in coming years. The topics are dealt with from electrophysiological, biochemical, anatomical, pharmacological, clinical, and behavioral perspectives to provide a thorough account of the functional roles played by these compounds in the part of the brain dealing with higher processes. The material is broad-based yet presented in a style that allows clinical and basic scientists alike easy access to integrated material across chapters and between sections.
目次
- Part 1 Cerebral cortex, excitatory amino acids, and their receptors: The anatomy of the cerebral cortex - aspects of neuronal morphology and organization, Stewart H.C. Hendry
- Diverse neuronal functions of the cerebral cortex, Barry W. Connors et al
- Calcium channels and the regulation of glutamate exocytosis, David G, Nicholls et al
- Glutamate receptor subunit composition in principal neurons and interneurons of the central nervous system, Maria Vincenza Catania et al
- Physiology of NMDA receptors and synaptic currents, Shaul Hestrin
- Physiology of AMPA receptors - biophysical characteristics that subserve integrative roles of synapses, Laurence O. Trussell, Thomas S. Otis
- Metabotropic glutamate receptors and cerebral cortex, Ferdinando Nicoletti et al. Part 2 Anatomy and physiology of excitatory amino acids in the cerebral cortex - I. form and functional (organizational aspects): The anatomy of glutamatergic transmission in the cerebral cortex, Fiorenzo Conti, Andrea Minelli
- Physiology of glutamatergic transmission in the cerebral cortex, Alex M. Thomson et al
- Excitatory amino acids in thalamocortical transmission, Richard J. Weinberg, Viktor N. Kharazia
- Mechanisms of dynamic afferent information processing in sensory neocortex, Raju Metherate, John H. Ashe
- Excitatory amino acids in corticofugal projections - microscopic evidence, Viktor N. Kharazia et al
- Physiological studies of the role of excitatory amino acids and their receptors in corticofugal projections, Thomas E. salt, Sean A. Eaton
- Muscarinic modulation of excitatory synaptic responses in cortical neurons, Robert W. Baughman et al. Part 3 Anatomy and physiology of excitatory amino acids in the cerebral cortex - II. molecular, cellular, and developmental (signalling) aspects: Inotropic glutamate receptors in vertebrate glial cells, Frank Kirchhoff, Helmut Kettenmann
- Astrocyte-neuron signalling, Vladimir Parpura et al
- Nitric oxide-synthesizing neurons in the cerebral cortex - anatomy and functional implications, Chiya Aoki et al
- The effects of nitric oxide on cortical function, Joseph A. Gally
- The role of excitatory amino acids in cortical development, Arnold R. Kriegstein et al
- Functional expression of NMDA receptors in developing neurons, N. Traverse Slater, David J. Rossi. (Part contents).
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