Molecular toxicology

著者

• Josephy, Philip David
• Mannervik, Bengt
• Ortiz de Montellano, Paul R.

書誌事項

Molecular toxicology

P. David Josephy with Bengt Mannervik and Paul Ortiz de Montellano

Oxford University Press, 1997

注記

Includes bibliographica references and index

内容説明・目次

内容説明

This book presents the biochemical and molecular biological fundamentals underlying toxicology and drug metabolism. It covers xenobiotic biotransformation; reactive intermediates and their interactions with macromolecules; cloning, expression, and analysis of the enzymes of biotransformation; and molecular toxicology of aromatic amines, nitrosames, polycyclic aromatic hydrocarbons, and chlorinated compounds.

目次

• Introduction
• 1. Biochemical Background
• 2. Molecular biology and its applications in toxicology
• 3. Biological oxidations
• 4. Superoxide and superoxide dismutase
• 5. Hydrogen peroxide and catalase
• 6. The respiratory burst
• 7. Lipid Peroxidation
• 8. Oxidative stress in the erythrocyte
• 9. Introduction to xenobiotic metabolism
• 10. Clucuronide formation
• 11. Glutathione and detoxication
• 12. Arylamine N-Acetyltransferase
• 13. Sulfotransferase
• 14. Cytochrom P-450
• 15. The AH receptor and the toxicity of chlorinated aromatic compounds
• 16. Identification of DNA adducts
• 17. Chemical mutagenesis
• 18. Carcinogenesis: the genetic targets
• 19. Polycyclic aromatic hydrocarbon carcinogenesis
• 20. Aromatic amines and other N-aryl compounds

「Nielsen BookData」 より

詳細情報

• NII書誌ID(NCID): BA28522298
• ISBN:
  • 0195093402
• LCCN: 95024812
• 出版国コード: us
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: New York ; Oxford
• ページ数/冊数: xiv, 368 p.
• 大きさ: 26 cm
• 分類:
  • LCC : RA1220.3
  • DC20 : 615.9
• 件名:
  • LCSH : Molecular toxicology