書誌事項

Epidemiology and control of neural tube defects

J. Mark Elwood, Julian Little, and J. Harold Elwood ; with contributions from Alastair V. Campbell ... [et al.]

(Monographs in epidemiology and biostatistics, v. 20)(Oxford medical publications)

Oxford University Press, 1992

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注記

Includes bibliographical references (p. [778]-903) and index

内容説明・目次

内容説明

Neural tube defects, spina bifida, anencephalus, and encephalocoele, are among the commonest severe congenital abnormalities in most countries. The last decade has seen many advances, including the use of antenatal diagnosis by chemical and ultrasound methods, population screening, and many new findings in epidemiology, culminating in the demonstration of the protective effect of folic acid on recurrences. The progress in both antenatal diagnosis and in aetiological research on neural tube defects has been particularly dramatic, and may well anticipate developments in regard to other congenital abnormalities. Primary prevention now appears as an attainable goal. This book presents a critical review of the extensive findings of epidemiological studies, discusses several methodological issues of wider relevance such as ascertainment, seasonal variation, ethical and legal issues. As well as providing a unique resource in regard to neural tube defects, much of the material is relevant to those with wider interests in the prevention, antenatal diagnosis, and control of major diseases.

目次

  • List of contributors
  • 1. An historical perspective
  • 2. Classification, anatomy, and embryology
  • 3. Ascertainment, registration, and assessment of exposure
  • 4. Geographical variation
  • 5. Ethnic origin and migration
  • 6. Secular trends
  • 7. Seasonal variation
  • 8. Clustering in time and space
  • 9. Distribution
  • 10. Early fetal loss
  • 11. Associations with multiple pregnancy
  • 12. Maternal age and reproductive history
  • 13. Maternal illness and drug use in pregnancy
  • 14. Socio-economic status and occupation
  • 15. Diet
  • 16. Risks in siblings and other relatives
  • 17. Genetic models
  • 18. Antenatal screening and diagnosis
  • 19. Ethical and legal issues
  • 20. Conclusions

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