書誌事項

Quinolone antibacterials

editors, J. Kuhlmann, A. Dalhoff, and H.-J. Zeiler ; contributors, D. Beermann ... [et al.]

(Handbook of experimental pharmacology, v. 127)

Springer, 1997

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

The quinolones continue to make a significant contribution in the fight against community or hospital-acquired infections and add a new dimension of antibacterial therapy. This volume describes in detail the chemistry, mode of action and pharmacodynamics of quinolones. A lot of effort has been undertaken to optimize structure-activity relationships with the aim of producing more potent drugs with an optimal therapeutic index.

目次

  • History and introduction
  • the chemistry of the quinolones - methods of synthesizing the quinolone ring system
  • chemistry in the periphery of the quinolones
  • mode of action
  • the in vitro antibacterial activity of quinolones - a review
  • pharmacokinetics of fluoroquinolones in experimental animals
  • pharmacodynamics of fluoroquinolones in experimental animals
  • interaction of quinolones with host-parasite-relationships
  • mechanisms of resistance to fluoro-quinolones
  • toxicology and safety pharmacology of quinolones
  • clinical pharmacology
  • concentration-effect relationship of the fluoroquinolones
  • clinical use of quinolones
  • future aspects.

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