The genetic basis of human cancer

著者

書誌事項

The genetic basis of human cancer

editors, Bert Vogelstein, Kenneth W. Kinzler

McGraw-Hill, Health Professions Division, c1998

大学図書館所蔵 件 / 全28件

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

Advances in the fields of genetics and molecular biology have made a great impact in oncology and cancer research. This book aims to present a thorough review of the fundamentals of genetics and human phenotypes, gene mutation, the Human Genome Project and genetic imprinting. From relatively rare to massively prevalent oncologic diseases and syndromes, the authors cover topics from melanoma, breast cancer and prostate cancer to Wilms Tumour. The chapter organization reflects clinical aspects; genetic loci, specific genes and implications for diagnosis.

目次

  • Part 1 Basic concepts in genetics: genetics, biochemistry and the molecular basis of variant human phenotypes
  • the nature and mechanisms of human gene mutation
  • the Human Genome Project
  • genetic imprinting in cancer. Part 2 Controls on cell growth: control of the cell cycle
  • apoptosis and cancer
  • oncogenes
  • tumour suppressor genes. Part 3A Inherited mutations - defects in DNA repair: xeroderma pigmentosa
  • ataxia telangiectasia
  • Bloom's syndrome
  • Fanconi anaemia
  • hereditary non-polyposis colorectal cancer
  • Werner syndrome. Part 3B defects in growing controlling genes: retinoblastoma
  • Li-Fraumenni syndrome
  • Wilms tumour
  • peripheral neurofibromatosis
  • central neurofibromatosis
  • renal carcinoma
  • multiple endocrine neoplasia
  • malignant melanoma
  • breast cancer
  • colorectal tumours. Part 4 Somatic mutations: chromosome translocations in leukemias and lymphomas
  • chromosome rearrangements human in solid tumours
  • gene amplification in human cancers - biological and clinical significance
  • pancreatic cancer
  • ovarian cancer
  • endometrial cancer
  • cervical cancer
  • bladder cancer
  • stomach cancer
  • prostate cancer
  • brain tumours
  • lung cancer
  • skin cancer
  • hepatocellular carcinoma
  • genetic testing for cancer.

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