Trypanosomiasis and leishmaniasis : biology and control
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Bibliographic Information
Trypanosomiasis and leishmaniasis : biology and control
CAB International, c1997
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Includes bibliographical references and index
Description and Table of Contents
Description
Trypanosomiasis and Leishmaniasis are related diseases caused by single celled organisms (protozoa) transmitted by insects. Between them these diseases are responsible for much suffering among humans and livestock and so a greater understanding of their biology is a vital part of the campaign to control them. Modern molecular techniques available for use in understanding the control of these diseases are becoming more sophisticated and are increasingly becoming universally applicable to a wide variety of diseases. This book brings together the research approaches that are used interchangeably to understand both Trypanosomiasis and Leishmaniasis. Examples of such fruitful integration can be seen in a number of research areas: genome mapping, molecular and population genetic approaches to epidemiology, studies on polyamine metabolism and possible targets for rational drug design, studies on cellular signalling as a route to understanding host-parasite interactions and studies on chemotherapy and drug resistance. There are also chapters that consider those features that are unique to either Trypanosomiasis or Leishmaniasis. Thus a broad overview of the biology of each disease from the molecular level right up to the whole animal is provided. Contributors come from the leading research groups working on these diseases and include clinicians, laboratory based researchers and social scientists. The book provides an up-to-date summary of the advances in the understanding of these diseases that have come about through the use of modern technologies. By presenting an integration of research into both Trypanosomiasis and Leishmaniasis this book provides an innovative contribution to the literature in this area. It is important reading for all parasitologists, pharmacologists, epidemiologists and clinicians working with these organisms. It is also a useful resource for veterinarians, public health workers, policy makers and social scientists concerned with Trypanosomiasis or Leishmaniasis.
Table of Contents
1: Preface: Current research into the biology and control of trypanosomiasis and leishmaniasis, Geoff Hide, Jeremy C. Mottram, Peter H. Holmes and Graham H.Coombs 2: Landmarks in trypanosome research, Keith Vickerman, FRS 3: Current public health status of the trypanosomiases and leishmaniases, David H. Molyneux 4: Sequencing and mapping the African trypanosome genome, Najib M.A. El-Sayedand John E. Donelson 5: The structure and biosynthesis of trypanosomatid Glycosylphosphatidylinositols, Michael A. J. Ferguson 6: A genetic analysis of the biosynthetic pathway of the Leishmania virulencefactor LPG, Salvatore J. Turco and Stephen M. Beverley 7: The biology of antigenic variation in African trypanosomes, J. DavidBarry 8: The expression sites for variant surface glycoproteins of Trypanosoma brucei,Piet Borst, Wilbert Bitter, Patricia Blundell, Michael Cross, Richard McCulloch, Gloria Rudenko, Martin C. Taylor and Fred van Leeuwen 9: Glycolysis of Kinetoplastida, Paul A. M. Michels, Veronique Hannaert and Barbara M. Bakker 10: Polyamine metabolism in trypanosomes, Alan H. Fairlamb and Sarah A. LeQuesne 11: Sterol metabolism of Leishmania and trypanosomes: Potential for chemotherapeutic exploitation, Michael L. Chance and L. John Goad 12: Proteinases of trypanosomes and Leishmania, Graham H. Coombs and Jeremy C. Mottram 13: Cell signalling in trypanosomatids, Etienne Pays, Sylvie Rolin and Stefan Magez 14: Protein phosphorylation and protein kinases in trypanosomatids, Michael Boshart and Jeremy C. Mottram 15: Chemotherapy of human leishmaniasis and trypanosomiasis, Simon L. Croft,Julio A.Urbina and Reto Brun 16: Drug resistance in trypanosomatids, Carole A. Ross and Diane V.Sutherland 17: The population dynamics and control of zoonotic visceral leishmaniasis, ChristopherDye, Orin Courtenay, David W. Kelly, Rupert J. Quinnell and Emmanuel Vidor 18: Molecular epidemiology of trypanosomatids, Geoff Hide 19: Evolutionary genetics of Trypanosoma, Leishmania and other microorganisms:Epidemiological, taxonomical and medical implications, Michel Tibayrenc 20: Current trends in parasite vector interactions, Susan C. Welburn and IanMaudlin 21: The socio-economic impact of African trypanosomiasis, Andrew James 22: Effects of trypanosomiasis on reproduction in domestic ruminants, Ian A.Jeffcoate and Peter H. Holmes 23: Control strategies for African trypanosomiases: Their sustainability and effectiveness, John Barrett
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