The selectins : initiators of leukocyte endothelial adhesion
著者
書誌事項
The selectins : initiators of leukocyte endothelial adhesion
（Advances in vascular biology, v. 3）
Harwood Academic, c1997
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
The selectins are the most recently discovered, and the smallest family of cell adhesion molecules. They not only mediate lymphocyte homing but their binding reaction also forms the first step in the entry of leukocytes to inflamed tissues. The inflammatory response is crucial in the host's defence against infectious micro-organisms, but can go drastically wrong, damaging host tissues in an acute reaction. Carbohydrate based selectin antagonists, as well as anti-selectin antibodies have been successfully used to combat this reaction in various animal models.Summarizing the present knowledge about the molecular mechanisms of selectin mediated cell adhesion, this volume forms an indispensable review of an important area of research. Its in-depth handling of the consequences of this research for various physiological and pathophysiological processes will also be vital to the clinician specialising in inflammatory disorders.
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