Neuronal nicotinic receptors : pharmacology and therapeutic opportunities

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Neuronal nicotinic receptors : pharmacology and therapeutic opportunities

edited by Stephen P. Arneric, Jorge D. Brioni

Wiley-Liss, c1999

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Includes bibliographical references and index

内容説明・目次

内容説明

Neuronal Nicotinic Receptors: Pharmacology and TherapeuticOpportunities Edited by Stephen P. Arneric and Jorge D. Brioni Nicotine's efficacy in the treatment of pain and anxiolysis, andits usefulness as a memory enhancer, have been suspected for manyyears, but research into the molecular biology of nicotinicacetylcholine receptors (nAChRs) traditionally has focused onsmoking cessation. Now, thanks to recent technological advances inthe molecular biology and electrophysiology of nAChRs, an abundanceof evidence has emerged in support of nAChR ligands in thetreatment of a range of CNS disorders, including Alzheimer'sdisease, Parkinson's disease, neuropathic pain, attention deficitdisorder, and depression. Featuring contributions from an international team of experts inthe field, this volume provides researchers and clinicians with acomprehensive review of nAChRs, their molecular biology,pharmacology, and clinical implications. Moving from the molecularto the clinical levels, the authors explore the latest developmentsin all areas of nAChR research, including: * Molecular biology and biochemistry of nAChRs * The physiological roles of nAChRs * Pharmacokinetics of nicotine-like alkaloids * Recent breakthroughs and emerging trends in nAChR medicinalchemistry * Current and emerging therapeutic applications of novel nAChRligands. A timely, authoritative review of basic research into nAChRs andtheir role in the development of new therapeutic strategies in thetreatment of a range of various CNS diseases, Neuronal NicotinicReceptors: Pharmacology and Therapeutic Opportunities is requiredreading for neuroscientists, pharmacologists, medicinal chemists,biological psychiatrists, and psychopharmacologists.

目次

MOLECULAR BIOLOGY AND BIOCHEMISTRY. Purification and Cloning of Nicotinic Acetylcholine Receptors (J.Lindstrom). Transcriptional Regulation of Neuronal Nicotinic Receptor SubunitGenes (D. Fornasari, et al.). Molecular Composition and Biophysical Characteristics of NicotinicReceptors (J. Ramirez-Latorre, et al.). Desensitization and the Regulation of Neuronal Nicotinic Receptors(M. Marks). Cell Lines as Models for Studies of Nicotinic AcetylcholineReceptors (R. Lukas). Stable Expression of Human Neuronal Nicotinic Receptors (B.Buisson, et al.). PHYSIOLOGICAL ROLES OF NICOTINIC RECEPTORS. Functional Anatomy of Nicotinic Acetylcholine Receptors inMammalian Brain (P. Clarke). Nicotinic Receptor Modulation of Neurotransmitter Release (S.Kaiser & S. Wonnacott). Functional Diversity of Nicotinic Acetylcholine Receptors in theMammalian Central Nervous System: Physiological Relevance (E.Pereira, et al.). Diverse Functions of Neuronal Nicotinic Receptors Determined bySubcellular Location (D. Berg, et al.). Immunosuppressive and Anti-inflammatory Properties of Nicotine (M.Sopori). PHARMACOKINETICS OF NICOTINE-LIKE ALKALOIDS. Pharmacokinetics and Metabolism of Nicotine and Related Alkaloids(N. Benowitz & P. Jacob). Nicotine and Related Compounds as PET and SPECT Ligands (V.Villemagne, et al). MEDICINAL CHEMISTRY. Natural Products as a Source of Nicotinic Acetylcholine ReceptorModulators and Leads for Drug Discovery (M. Holladay, etal.). Nicotinic Cholinergic Receptor Pharmacophores (R. Glennon & M.Dukat). CURRENT AND POTENTIAL THERAPEUTIC APPLICATIONS. Neuronal Nicotinic Receptor Channel Dysfunction in a Human EpilepsySyndrome (D. Bertrand & S. Berkovic). The Role of Nicotine and Nicotinic Receptors in Psychopathology (S.Leonard, et al.). Nicotine and Non-Nicotine Formulations for Smoking Cessation (S.Leischow & G. Cook). Preclinical Evidence on the Neuroprotective Effects of NicotinicLigands (D. Donnelly-Roberts & J. Brioni). Transdermal Nicotine Treatment of Attention Deficit HyperactivityDisorder (E. Levin, et al.). Neuronal Nicotinic Receptors: New Targets in the Treatment of Pain(C. Flores & K. Hargreaves). Subtype-Selective nAChR Agonists for the Treatment of NeurologicalDisorders: SIB-1508Y and SIB-1553A (F. Menzaghi, et al.). Nicotinic Acetylcholine Receptor-Targeted Compounds: A Summary ofthe Development Pipeline and Therapeutic Potential (M. Decker &S. Arneric). Index.

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