Diagonosis of colorectal and ovarian carcinoma : application of iimmunoscintigraphic technology
著者
書誌事項
Diagonosis of colorectal and ovarian carcinoma : application of iimmunoscintigraphic technology
M. Dekker, c1992
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内容説明・目次
内容説明
This volume discusses the preclinical and clinical experience with the B72.3 monoclonal anti-body as a tumour targeting agent - emphasizing the results of studies utilizing site-specifically radiolabelled B72.3 (CYT-103-111In; OncoScint CR103). Focusing on OncoStint's ability to determine the presence and extent of disease in colorectal or ovarian cancer patients, this book: reviews the generation of the B72.3 monoclonal antibody and its development from preclinical trials to the first approved cancer imaging technology; presents the results of clinical trials of radioiodinated and indium-111 labelled material for colorectal cancer patients and considers the contribution of this procedure to their care; describes the use of CYT-103-111In as a presurgical diagnostic agent in ovarian cancer patients and its impact on their surgical management; and offers examples of normal biodistribution, tumour localization, and the potential pitfalls in image interpretation. The book is intended for radiologists, internists, oncologists, nuclear medicine physicians, gastroenterologists, obstetricians/gynaecologists, immunologists and surgeons.
目次
- An overview of radioimmunoimaging, Samuel Halpern
- generation and characterization of monoclonal antibody B72.3 - experimental and preclinical studies, David Colcher, et al
- imaging of colorectal carcinoma with iodine-131 B72.3 monoclonal antibody, Jorge A. Carrasquillo
- monoclonal antibody B72.3 immunoscintography in the follow-up of patients with colorectal cancer, Secondo Lastoria and Marco Salvatore
- multicentre clinical trials of monoclonal antibody B72.3- GYK-DTPA-111In (CYT-103-111/in
- oncoscint CR103) in patients with colorectal carcinoma, Hani Abdel-Nabi and Ralph J. Doerr
- oncoscint CR-103 imaging in the surgical management of patients with colorectal cancer, Ralph J. Doerr and Hani Abdel-Nabi
- multicentre clinical trial of 111In-CYT-103 in patients with ovarian cancer, Donald G. Gallup
- impact of 111In-CYT 103 imaging on the surgical management of patients with ovarian cancer, Earl A. Surwit
- oncoscint image atlas, Robert T. Maguire
- immunopharmacokinetics of 111In-CYT-103 in ovarian cancer patients, William J. Jusko, et al
- a practical approach to planar and SPECT imaging of indium-111 CYT-103, B. David Collier, et al
- future directions in tumour radioimmunodetection, Thomas J. McKearn.
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